ArticleCarcinogenesis2010
Inherited variation in immune genes and pathways and glioblastoma risk.
Article in Carcinogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Weighing the risk: a scoping review on the relationship between obesity and glioma.Cancer causes & control : CCC · 2026Article
- The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene-Environment Interaction Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Significance ofClinical Medicine Insights. Oncology · 2025Article
- Glioma.Nature reviews. Disease primers · 2024Review
- Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population.Scientific reports · 2022Article
- Dissecting Molecular Features of Gliomas: Genetic Loci and Validated Biomarkers.International journal of molecular sciences · 2020Review
- Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility.Oncotarget · 2016Article
- Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.Journal of neuro-oncology · 2016Article
- Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.Cancer letters · 2015Article
- Epidemiologic and molecular prognostic review of glioblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Review
- The epidemiology of glioma in adults: a "state of the science" review.Neuro-oncology · 2014Review
- Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Antihistamine use and immunoglobulin E levels in glioma risk and prognosis.Cancer epidemiology · 2013Article
- An integrative characterization of recurrent molecular aberrations in glioblastoma genomes.Nucleic acids research · 2013Article
- Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.Neuro-oncology · 2013Article
- Integration of epidemiology, immunobiology, and translational research for brain tumors.Annals of the New York Academy of Sciences · 2013Article
- Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.Genetic epidemiology · 2013Article
- Epigenetic biomarkers of T-cells in human glioma.Epigenetics · 2012Article
- Recent advances in the molecular understanding of glioblastoma.Journal of neuro-oncology · 2012Review
- Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.Neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
29 authors at 12 institutions in 5 countries.
Funding
Abstract
To determine whether inherited variations in immune function single-nucleotide polymorphisms (SNPs), genes or pathways affect glioblastoma risk, we analyzed data from recent genome-wide association studies in conjunction with predefined immune function genes and pathways. Gene and pathway analyses were conducted on two independent data sets using 6629 SNPs in 911 genes on 17 immune pathways from 525 glioblastoma cases and 602 controls from the University of California, San Francisco (UCSF) and a subset of 6029 SNPs in 893 genes from 531 cases and 1782 controls from MD Anderson (MDA). To further assess consistency of SNP-level associations, we also compared data from the UK (266 cases and 2482 controls) and the Mayo Clinic (114 cases and 111 controls). Although three correlated epidermal growth factor receptor (EGFR) SNPs were consistently associated with glioblastoma in all four data sets (Mantel-Haenzel P values = 1 × 10⁻⁵ to 4 × 10⁻³), independent replication is required as genome-wide significance was not attained. In gene-level analyses, eight immune function genes were significantly (minP < 0.05) associated with glioblastoma; the IL-2RA (CD25) cytokine gene had the smallest minP values in both UCSF (minP = 0.01) and MDA (minP = 0.001) data sets. The IL-2RA receptor is found on the surface of regulatory T cells potentially contributing to immunosuppression characteristic of the glioblastoma microenvironment. In pathway correlation analyses, cytokine signaling and adhesion-extravasation-migration pathways showed similar associations with glioblastoma risk in both MDA and UCSF data sets. Our findings represent the first systematic description of immune genes and pathways that characterize glioblastoma risk.
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Registered trials
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