ArticleProceedings. Biological sciences2011
Warm fish with cold hearts: thermal plasticity of excitation-contraction coupling in bluefin tuna.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Comparative analysis of ventricular stiffness across species.Physiological reports · 2024Review
- Ontogeny of cardiomyocytes: ultrastructure optimization to meet the demand for tight communication in excitation-contraction coupling and energy transfer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Evolution of the cardiac dyad.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Rising floor and dropping ceiling: organ heterogeneity in response to cold acclimation of the largest extant amphibian.Proceedings. Biological sciences · 2022Article
- Proteomic analysis of temperature-dependent developmental plasticity within the ventricle of juvenile Atlantic salmon (Current research in physiology · 2022Article
- Effects of acute warming on cardiac and myotomal sarco(endo)plasmic reticulum ATPase (SERCA) of thermally acclimated brown trout (Salmo trutta).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Thermal effects on red muscle contractile performance in deep-diving, large-bodied fishes.Fish physiology and biochemistry · 2020Article
- Skeletal muscle and cardiac transcriptomics of a regionally endothermic fish, the Pacific bluefin tuna, Thunnus orientalis.BMC genomics · 2020Article
- Direct measurement of swimming and diving kinematics of giant Atlantic bluefin tuna (Royal Society open science · 2019Article
- Characterization of the functional and anatomical differences in the atrial and ventricular myocardium from three species of elasmobranch fishes: smooth dogfish (Mustelus canis), sandbar shark (Carcharhinus plumbeus), and clearnose skate (Raja eglanteria).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant.Scientific reports · 2017Article
- Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.BMC genomics · 2017Article
- Temperature-induced cardiac remodelling in fish.The Journal of experimental biology · 2017Review
- Fisheries conservation on the high seas: linking conservation physiology and fisheries ecology for the management of large pelagic fishes.Conservation physiology · 2016Article
- Development and validation of a mixed-tissue oligonucleotide DNA microarray for Atlantic bluefin tuna, Thunnus thynnus (Linnaeus, 1758).BMC genomics · 2015Article
- Assessing niche width of endothermic fish from genes to ecosystem.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cardiac function in an endothermic fish: cellular mechanisms for overcoming acute thermal challenges during diving.Proceedings. Biological sciences · 2015Article
- The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle.Frontiers in physiology · 2015Article
- Species- and chamber-specific responses of 12 kDa FK506-binding protein to temperature in fish heart.Fish physiology and biochemistry · 2014Article
- Seasonal acclimatization of the cardiac action potential in the Arctic navaga cod (Eleginus navaga, Gadidae).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bluefin tuna have a unique physiology. Elevated metabolic rates coupled with heat exchangers enable bluefin tunas to conserve heat in their locomotory muscle, viscera, eyes and brain, yet their hearts operate at ambient water temperature. This arrangement of a warm fish with a cold heart is unique among vertebrates and can result in a reduction in cardiac function in the cold despite the elevated metabolic demands of endothermic tissues. In this study, we used laser scanning confocal microscopy and electron microscopy to investigate how acute and chronic temperature change affects tuna cardiac function. We examined the temporal and spatial properties of the intracellular Ca2+ transient (Δ[Ca2+]i) in Pacific bluefin tuna (Thunnus orientalis) ventricular myocytes at the acclimation temperatures of 14°C and 24°C and at a common test temperature of 19°C. Acute (less than 5 min) warming and cooling accelerated and slowed the kinetics of Δ[Ca2+]i, indicating that temperature change limits cardiac myocyte performance. Importantly, we show that thermal acclimation offered partial compensation for these direct effects of temperature. Prolonged cold exposure (more than four weeks) increased the amplitude and kinetics of Δ[Ca2+]i by increasing intracellular Ca2+ cycling through the sarcoplasmic reticulum (SR). These functional findings are supported by electron microscopy, which revealed a greater volume fraction of ventricular SR in cold-acclimated tuna myocytes. The results indicate that SR function is crucial to the performance of the bluefin tuna heart in the cold. We suggest that SR Ca2+ cycling is the malleable unit of cellular Ca2+ flux, offering a mechanism for thermal plasticity in fish hearts. These findings have implications beyond endothermic fish and may help to delineate the key steps required to protect vertebrate cardiac function in the cold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.