ArticleCritical care (London, England)2010
Cerebral microcirculation is impaired during sepsis: an experimental study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 3 of them syntheses that pooled it.
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Who cites it
109 citing papers in PubMed, 3 syntheses or guidelines pooled it, 206 citations in OpenAlex.
- The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation.Molecular neurobiology · 2023Pooled it
- Cerebral hemodynamics in sepsis assessed by transcranial Doppler: a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2017Pooled it
- Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review.Critical care (London, England) · 2014Pooled it
- Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial.Critical care (London, England) · 2018Trial
- Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium.Critical care (London, England) · 2012Trial
- ARISE framework: a temporal, multi-organ view of perfusion in sepsis.Internal and emergency medicine · 2026Review
- Current knowledge and challenges of sepsis-associated encephalopathy.Intensive care medicine · 2026Review
- Brain endothelial PTPRO drives LPS-induced metabolic reprogramming and neuroinflammation in sepsis-associated encephalopathy.Journal of neuroinflammation · 2026Article
- Association of Serum Sodium Levels and Delirium in Patients with Sepsis: A Retrospective Study.Biomedicines · 2026Article
- Recombinant TsP53 mitigates inflammation and blood-brain barrier disruption in CLP-induced septic mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Role of the intestinal microbiota in sepsis-associated encephalopathy.Burns & trauma · 2026Review
- Retinal Perfusion and Injury in Sepsis and after Major Surgery.Ophthalmology science · 2026Article
- Minimally-Invasive Imaging of Sublingual Vessels-A New Method to Study Microvascular Changes in Mice.Life (Basel, Switzerland) · 2025Article
- Bosutinib mitigates inflammation in experimental sepsis.European journal of clinical investigation · 2025Article
- Sepsis in patients with severe TBI: a retrospective CT scoring study.International journal of emergency medicine · 2025Article
- Alterations in Regional Brain Microcirculation in Patients with Sepsis: A Prospective Study Using Contrast-Enhanced Brain Ultrasound.Neurocritical care · 2025Article
- Study on the predictive value of early microcirculation perfusion indicators combined with neuroelectrophysiological monitoring for the occurrence and prognosis of sepsis-associated encephalopathy in neurocritical care patients.Frontiers in neurology · 2025Article
- Peripheral inflammation is accompanied by cerebral hypoperfusion in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Transcapillary POJournal of vascular research · 2025Article
- Non-invasive point-of-care optical technique for continuous in vivo assessment of microcirculatory function: Application to a preclinical model of early sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPathophysiology of brain dysfunction due to sepsis remains poorly understood. Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock.
methodsFifteen anesthetized, invasively monitored, and mechanically ventilated female sheep were allocated to a sham procedure (n = 5) or sepsis (n = 10), in which peritonitis was induced by intra-abdominal injection of autologous faeces. Animals were observed until spontaneous death or for a maximum of 20 hours. In addition to global hemodynamic assessment, the microcirculation of the cerebral cortex was evaluated using Sidestream Dark-Field (SDF) videomicroscopy at baseline, 6 hours, 12 hours and at shock onset. At least five images of 20 seconds each from separate areas were recorded at each time point and stored under a random number to be analyzed, using a semi-quantitative method, by an investigator blinded to time and condition.
resultsAll septic animals developed a hyperdynamic state associated with organ dysfunction and, ultimately, septic shock. In the septic animals, there was a progressive decrease in cerebral total perfused vessel density (from 5.9 ± 0.9 at baseline to 4.8 ± 0.7 n/mm at shock onset, P = 0.009), functional capillary density (from 2.8 ± 0.4 to 2.1 ± 0.7 n/mm, P = 0.049), the proportion of small perfused vessels (from 95 ± 3 to 85 ± 8%, P = 0.02), and the total number of perfused capillaries (from 22.7 ± 2.7 to 17.5 ± 5.2 n/mm, P = 0.04). There were no significant changes in microcirculatory flow index over time. In sham animals, the cerebral microcirculation was unaltered during the study period.
conclusionsIn this model of peritonitis, the cerebral microcirculation was impaired during sepsis, with a significant reduction in perfused small vessels at the onset of septic shock. These alterations may play a role in the pathogenesis of septic encephalopathy.
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