ArticleJournal of clinical periodontology2010
Association of salivary lysozyme and C-reactive protein with metabolic syndrome.
Article in Journal of clinical periodontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- A Systematic Review of Proteomics in Obesity: Unpacking the Molecular Puzzle.Current obesity reports · 2024Pooled it
- C-Reactive Protein in Saliva as a Non-Invasive Marker of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Association Between Continuous Consumption of Yogurt Fermented withJournal of clinical medicine · 2026Article
- Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease.Clinical proteomics · 2025Article
- Periodontitis and edentulism as risk indicators for mortality: Results from a prospective cohort study with 20 years of follow-up.Journal of periodontal research · 2023Article
- Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance.World journal of diabetes · 2014Article
- Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort.Journal of clinical periodontology · 2014Article
- Salivary biomarkers for detection of systemic diseases.PloS one · 2013Article
- Association between salivary pH and metabolic syndrome in women: a cross-sectional study.BMC oral health · 2012Article
- Salivary uric acid as a noninvasive biomarker of metabolic syndrome.Diabetology & metabolic syndrome · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionSalivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.
methodsUtilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C-reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD.
resultsMetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20-3.12, p-value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64-4.15, p=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09-3.52), p=0.02]. In both subgroups, CRP was not significantly associated with metS.
conclusionSLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.
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