ReviewStress (Amsterdam, Netherlands)2011
Allopregnanolone and suppressed hypothalamo-pituitary-adrenal axis stress responses in late pregnancy in the rat.
Review in Stress (Amsterdam, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Females in Psychedelic Research: A Perspective for Advancing Research and Practice.ACS pharmacology & translational science · 2025Review
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.bioRxiv : the preprint server for biology · 2024Article
- The impact of pubertal stress and adult hormone exposure on the transcriptome of the developing hypothalamus.Stress (Amsterdam, Netherlands) · 2024Article
- GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder.CNS drugs · 2023Review
- Enduring impact of childhood adversity: Affective modulation of acoustic startle response during pregnancy and postpartum.Physiology & behavior · 2023Article
- The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies.Biomolecules · 2022Review
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age.Journal of veterinary internal medicine · 2019Article
- The parental brain and behavior: A target for endocrine disruption.Frontiers in neuroendocrinology · 2019Review
- Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression.Frontiers in cellular neuroscience · 2019Review
- Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience.F1000Research · 2019Review
- Modeling prenatal opioid exposure in animals: Current findings and future directions.Frontiers in neuroendocrinology · 2018Review
- Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.Psychoneuroendocrinology · 2018Article
- A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression.Frontiers in endocrinology · 2018Article
- Juvenile social isolation affects maternal care in rats: involvement of allopregnanolone.Psychopharmacology · 2017Article
- Hydrocortisone therapy in a cat with vasopressor-refractory septic shock and suspected critical illness-related corticosteroid insufficiency.Clinical case reports · 2017Article
- Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.Biological psychiatry · 2017Article
- Blunted neuroactive steroid and HPA axis responses to stress are associated with reduced sleep quality and negative affect in pregnancy: a pilot study.Psychopharmacology · 2016Article
- Epigenetic and transgenerational reprogramming of brain development.Nature reviews. Neuroscience · 2015Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In rats, late pregnancy is associated with suppressed hypothalamo-pituitary-adrenal (HPA) axis responses to a variety of stressful stimuli. The result is reduced corticosterone secretion following stress, which is considered to give some protection to the fetuses from adverse glucocorticoid programming and limits the catabolic effect of corticosterone, hence minimizing maternal energy expenditure. We have used a model of immune challenge in which systemic administration of the cytokine, interleukin-1β (IL-1β), allows study of the mechanisms underlying HPA axis hyporesponsiveness in late pregnancy. Suppressed responsiveness of parvocellular paraventricular nucleus (pPVN) corticotropin-releasing hormone neurons, and hence the HPA axis, following IL-1β in late pregnancy is evidently explained by presynaptic inhibition of noradrenaline release in the pPVN, owing to increased endogenous opioid peptide enkephalin production in brainstem nucleus tractus solitarii neurons. Allopregnanolone, a neurosteroid metabolite of progesterone, signals the pregnancy status of the animal to the brain and stimulates opioid production in the brainstem. In this review, we discuss the supporting evidence for these mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.