ArticleAnalytical chemistry2010
High-resolution differential ion mobility separations using planar analyzers at elevated dispersion fields.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Improving Peak Capacity in Glycan Ion Mobility Separations through Traveling Wave-Based Ion Heating.Journal of the American Society for Mass Spectrometry · 2026Article
- Oxygen enhanced plasma discharge and its application as carrier gas for high-field asymmetric ion mobility spectroscopy.Analytical and bioanalytical chemistry · 2025Article
- Performance Enhancements in Differential Ion Mobility Spectrometry-Mass Spectrometry (DMS-MS) by Using a Modified CaptiveSpray Source.Journal of the American Society for Mass Spectrometry · 2018Article
- Differential Mobility-Mass Spectrometry Double Spike Isotope Dilution Study of Release of β-Methylaminoalanine and Proteinogenic Amino Acids during Biological Sample Hydrolysis.Scientific reports · 2018Article
- Variables Affecting the Internal Energy of Peptide Ions During Separation by Differential Ion Mobility Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2017Article
- Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations.Analytical chemistry · 2017Article
- Improved Differential Ion Mobility Separations Using Linked Scans of Carrier Gas Composition and Compensation Field.Journal of the American Society for Mass Spectrometry · 2015Article
- Optimization of peptide separations by differential ion mobility spectrometry.Journal of the American Society for Mass Spectrometry · 2014Article
- Improved isobaric tandem mass tag quantification by ion mobility mass spectrometry.Rapid communications in mass spectrometry : RCM · 2014Article
- Differential ion mobility separations in up to 100% helium using microchips.Journal of the American Society for Mass Spectrometry · 2014Article
- Separation of protein conformers by differential ion mobility in hydrogen-rich gases.Analytical chemistry · 2013Article
- Overtone mobility spectrometry: part 5. Simulations and analytical expressions describing overtone limits.Journal of the American Society for Mass Spectrometry · 2013Article
- High-resolution differential ion mobility spectrometry of a protein.Analytical chemistry · 2013Article
- Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.Mass spectrometry (Tokyo, Japan) · 2013Article
- High-definition differential ion mobility spectrometry with resolving power up to 500.Journal of the American Society for Mass Spectrometry · 2013Article
- Separation of variant methylated histone tails by differential ion mobility.Analytical chemistry · 2012Article
- Ion mobility separation of variant histone tails extending to the "middle-down" range.Analytical chemistry · 2012Article
- Accelerated high-resolution differential ion mobility separations using hydrogen.Analytical chemistry · 2011Article
- Separation of a set of peptide sequence isomers using differential ion mobility spectrometry.Analytical chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The ion mobility spectrometry (IMS) methods are grouped into conventional IMS, based on the absolute ion mobility, and differential or field asymmetric waveform IMS (FAIMS), based on mobility differences between strong and weak electric fields. A key attraction of FAIMS is substantial orthogonality to mass spectrometry (MS). Although several FAIMS/MS platforms were commercialized, their utility was limited by FAIMS resolving power, typically ∼10-20. Recently, gas mixtures comprising up to 75% He have enabled resolving power >100 that permits separation of numerous heretofore "coeluting" isomers. This performance opens major new proteomic and other biological applications. Here, we show that raising the separation field by ∼35% over the previous 21 kV/cm provides similar or better resolution (with resolving powers of >200 for multiply charged peptides) using only 50% He, which avoids problems due to elevated pressure and He content in the mass spectrometer. The heating of ions by the separation field in this regime exceeds that at higher He content but weaker field, inducing greater isomerization of labile species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.