Evidence map›Paper›PMID 20666386›Full record

ArticleInorganic chemistry2010

Bioinspired heme, heme/nonheme diiron, heme/copper, and inorganic NOx chemistry: *NO((g)) oxidation, peroxynitrite-metal chemistry, and *NO((g)) reductive coupling.

Mark P Schopfer, Jun Wang, Kenneth D Karlin

Abstract read
In one paragraph

Article in Inorganic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Complete denitrification of nitrate and nitrite to NChemical communications (Cambridge, England) · 2020
    Article
  7. Article
  8. Article
  9. Review
  10. A mononuclear nonheme {FeNO}Chemical science · 2018
    Article
  11. Copper(I)/NOJournal of the American Chemical Society · 2017
    Article
  12. Article
  13. A Peroxynitrite Dicopper Complex: Formation via Cu-NO and Cu-OJournal of the American Chemical Society · 2016
    Article
  14. Article
  15. Isocyanide or nitrosyl complexation to hemes with varying tethered axial base ligand donors: synthesis and characterization.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Nitric oxide generation from heme/copper assembly mediated nitrite reductase activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark P SchopferDepartment of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA.
Jun Wang
Kenneth D Karlin

Funding

NEW COPPER(I) CHEMISTRY-MODELS FOR METALLOPROTEINSR01GM028962 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI KARLIN, KENNETH D. · 1985 to 2020
$6.7M
Heme/Copper and Heme/Nonheme Iron O(2) and NO ReactivityR01GM060353 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KARLIN, KENNETH D. · 2000 to 2020
$5.9M
BIOINORGANIC COPPER COORDINATION CHEMISTRYR37GM028962 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KARLIN, KENNETH D. · 1993 to 2002
$882k
NIGMS NIH HHS GM28962NIGMS NIH HHS GM60353NIGMS NIH HHS R01 GM028962NIGMS NIH HHS R01 GM060353
6 · The paper itself

Abstract

The focus of this Forum Article highlights work from our own laboratories and those of others in the area of biochemical and biologically inspired inorganic chemistry dealing with nitric oxide [nitrogen monoxide, *NO((g))] and its biological roles and reactions. The latter focus is on (i) oxidation of *NO((g)) to nitrate by nitric oxide dioxygenases (NODs) and (ii) reductive coupling of two molecules of *NO((g)) to give N(2)O(g). In the former case, NODs are described, and the highlighting of possible peroxynitrite/heme intermediates and the consequences of this are given by a discussion of recent works with myoglobin and a synthetic heme model system for NOD action. Summaries of recent copper complex chemistries with *NO((g)) and O(2)(g), leading to peroxynitrite species, are given. The coverage of biological reductive coupling of *NO((g)) deals with bacterial nitric oxide reductases (NORs) with heme/nonheme diiron active sites and on heme/copper oxidases such as cytochrome c oxidase, which can mediate the same chemistry. Recently designed protein and synthetic model compounds (heme/nonheme/diiron or heme/copper) as functional mimics are discussed in some detail. We also highlight examples from the chemical literature, not necessarily involving biologically relevant metal ions, that describe the oxidation of *NO((g)) to nitrate (or nitrite) and possible peroxynitrite intermediates or reductive coupling of *NO((g)) to give nitrous oxide.

Indexed as

CopperHemeModels, MolecularNitric OxideOxidation-ReductionOxygenasesPeroxynitrous AcidCopperHemeNitric Oxidenitric oxide dioxygenaseOxygenasesPeroxynitrous Acid

Identifiers

PMID20666386
PMCPMC2920632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.