ArticleJournal of gastroenterology2010
Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study.
Article in Journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.Frontiers in immunology · 2022Article
- A new practical classification of desmoplastic reaction in endoscopic forceps biopsy of colorectal cancer.Histology and histopathology · 2021Article
- INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival.Science advances · 2021Article
- Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer.Oncotarget · 2018Article
- Article
- Poorly differentiated component in gastric pinch biopsies predicts submucosal invasion.Diagnostic pathology · 2014Article
- Diagnosis of desmoplastic reaction by immunohistochemical analysis, in biopsy specimens of early colorectal carcinomas, is efficacious in estimating the depth of invasion.International journal of molecular sciences · 2013Article
- Myofibroblast activation in colorectal cancer lymph node metastases.British journal of cancer · 2013Article
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Authors and funding
25 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have previously demonstrated a relationship between the depth of submucosal invasion (SM depth) and the frequency of lymph node metastasis in resected submucosal invasive colorectal cancers (SICRCs). Here, we assessed the desmoplastic reaction (DR) in pretreatment biopsy specimens of SICRC to predict the SM depth.
methodsA total of 359 patients with SICRCs, who had undergone surgical or endoscopic mucosal resection, were enrolled. The SM depth of the SICRC lesions was evaluated according to the procedure established by the Japanese Society for Cancer of the Colon and Rectum, and the patients' corresponding pretreatment biopsy specimens were examined histologically to evaluate the prevalence of DR.
resultsFor pedunculated SICRCs, the prevalence of DR in pretreatment biopsy specimens was significantly higher in moderately differentiated than in well-differentiated adenocarcinomas, but was not significantly related to SM depth. For nonpedunculated SICRCs, the prevalence of DR in pretreatment biopsy specimens was significantly related to histological type, tumor size, and SM depth. When non-pedunculated SICRCs were further divided using a specific cutoff value of 1000 μm for SM depth, the DR positivity rate in pretreatment biopsy specimens was significantly higher in SICRCs with an SM depth of ≥1000 μm (termed "SM massive CRCs") than in cases where the SM depth was <1000 μm (termed "SM slight CRCs").
conclusionsDetection of DR in pretreatment biopsy specimens is useful for the prediction of SM depth in nonpedunculated SICRCs, and may be useful for the selection of such cases that would be treatable by endoscopic mucosal resection and endoscopic submucosal dissection (EMR/ESD).
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