ArticleMolecular systems biology2010
Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Fibrinolysis-unrelated functions of the plasminogen/plasmin system: A gateway to successful parasitism?Current research in parasitology & vector-borne diseases · 2026Review
- A Comprehensive Multi-Omics Study of Serum Alterations in Red Deer Infected by the Liver FlukePathogens (Basel, Switzerland) · 2024Article
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- Functional characterization of Clonorchis sinensis choline transporter.Parasites, hosts and diseases · 2023Article
- Preliminary insights on the metabolomics ofFrontiers in molecular biosciences · 2023Article
- Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics.Frontiers in parasitology · 2022Review
- Metabolic profiling of liver and faeces in mice infected with echinococcosis.Parasites & vectors · 2021Article
- Editorial: Systems Biology of Hosts, Parasites and Vectors.Frontiers in cellular and infection microbiology · 2021Article
- Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes,Metabolites · 2020Article
- Perturbations of Metabolomic Profiling of Spleen From Rats Infected WithFrontiers in molecular biosciences · 2020Article
- In vitro metabolomic footprint of the Echinococcus multilocularis metacestode.Scientific reports · 2019Article
- Article
- Potential serum biomarkers and metabonomic profiling of serum in ischemic stroke patients using UPLC/Q-TOF MS/MS.PloS one · 2017Article
- Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The newest "omics"--metagenomics and metabolomics--enter the battle against the neglected tropical diseases.PLoS neglected tropical diseases · 2015Article
- Multidimensional approaches to NMR-based metabolomics.Analytical chemistry · 2014Review
- 1H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice.PloS one · 2014Article
- Systematic evaluation of extraction methods for multiplatform-based metabotyping: application to the Fasciola hepatica metabolome.Analytical chemistry · 2012 · on this mapArticle
- Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.Journal of proteome research · 2012Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
We characterize the integrated response of a rat host to the liver fluke Fasciola hepatica using a combination of (1)H nuclear magnetic resonance spectroscopic profiles (liver, kidney, intestine, brain, spleen, plasma, urine, feces) and multiplex cytokine markers of systemic inflammation. Multivariate mathematical models were built to describe the main features of the infection at the systems level. In addition to the expected modulation of hepatic choline and energy metabolism, we found significant perturbations of the nucleotide balance in the brain, together with increased plasma IL-13, suggesting a shift toward modulation of immune reactions to minimize inflammatory damage, which may favor the co-existence of the parasite in the host. Subsequent analysis of brain extracts from other trematode infection models (i.e. Schistosoma mansoni, and Echinostoma caproni) did not elicit a change in neural nucleotide levels, indicating that the neural effects of F. hepatica infection are specific. We propose that the topographically extended response to invasion of the host as characterized by the modulated global metabolic phenotype is stratified across several bio-organizational levels and reflects the direct manipulation of host-nucleotide balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.