ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2010
Measuring endogenous 5-HT release by emission tomography: promises and pitfalls.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 146 citations in OpenAlex.
- Measuring endogenous changes in serotonergic neurotransmission with [Translational psychiatry · 2019Trial
- Central noradrenaline transporter availability in highly obese, non-depressed individuals.European journal of nuclear medicine and molecular imaging · 2017Trial
- Fluctuations in [¹¹C]SB207145 PET binding associated with change in threat-related amygdala reactivity in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Serotonin 2A receptor agonist binding in the human brain with [¹¹C]Cimbi-36.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Central 5-HT4 receptor binding as biomarker of serotonergic tonus in humans: a [11C]SB207145 PET study.Molecular psychiatry · 2014Trial
- Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study.Molecular psychiatry · 2012Trial
- Diversity of words and words for diversity.Frontiers in psychiatry · 2026Article
- Article
- Dynamics of human serotonin synthesis differentially link to reward anticipation and feedback.Molecular psychiatry · 2025Article
- The Relationship Between Impulsivity Traits and In Vivo Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in Healthy Individuals: A Double-Tracer PET Study with C-11 DASB and C-11 MDL100907.International journal of molecular sciences · 2024Article
- Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024Article
- In Vivo Serotonin 5-HT2A Receptor Availability and Its Relationship with Aggression Traits in Healthy Individuals: A Positron Emission Tomography Study with C-11 MDL100907.International journal of molecular sciences · 2023Article
- Fifty years on: Serotonin and depression.Journal of psychopharmacology (Oxford, England) · 2023Review
- Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals.Human brain mapping · 2022Article
- Mechanistic modeling as an explanatory tool for clinical treatment of chronic catatonia.Frontiers in pharmacology · 2022Article
- The role of neuroimaging in Parkinson's disease.Journal of neurochemistry · 2021Review
- PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- [Frontiers in neuroscience · 2021Article
- Quantitative Rodent Brain Receptor Imaging.Molecular imaging and biology · 2020Review
- Serotonin release measured in the human brain: a PET study with [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Molecular in vivo neuroimaging techniques can be used to measure regional changes in endogenous neurotransmitters, evoked by challenges that alter synaptic neurotransmitter concentration. This technique has most successfully been applied to the study of endogenous dopamine release using positron emission tomography, but has not yet been adequately extended to other neurotransmitter systems. This review focuses on how the technique has been applied to the study of the 5-hydroxytryptamine (5-HT) system. The principles behind visualising fluctuations in neurotransmitters are introduced, with reference to the dopaminergic system. Studies that aim to image acute, endogenous 5-HT release or depletion at 5-HT receptor targets are summarised, with particular attention to studies in humans. Radiotracers targeting the 5-HT(1A), 5-HT(2A), and 5-HT(4) receptors and the serotonin reuptake transporter have been explored for their sensitivity to 5-HT fluctuations, but with mixed outcomes; tracers for these targets cannot reliably image endogenous 5-HT in humans. Shortcomings in our basic knowledge of the mechanisms underlying changes in binding potential are addressed, and suggestions are made as to how the selection of targets, radiotracers, challenge paradigms, and experimental design might be optimised to improve our chances of successfully imaging endogenous neurotransmitters in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.