ArticleLab animal2010
An alternative method for intrathymic injections in mice.
Article in Lab animal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Ultrasound-Guided Intra-thymic Cell Injection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice.Journal of visualized experiments : JoVE · 2022Article
- Ultrasound Monitoring of Thymus Involution in Septic Mice.Ultrasound in medicine & biology · 2021Article
- AAV9-mediated AIRE gene delivery clears circulating antibodies and tissue T-cell infiltration in a mouse model of autoimmune polyglandular syndrome type-1.Clinical & translational immunology · 2020Article
- Thymic regulatory T cells arise via two distinct developmental programs.Nature immunology · 2019Article
- CD8αα intraepithelial lymphocytes arise from two main thymic precursors.Nature immunology · 2017Article
- Intrathymic Injection.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice.Ultrasound in medicine & biology · 2015Article
- Lipid phosphate phosphatase 3 enables efficient thymic egress.The Journal of experimental medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The thymus is a bi-lobed lymphatic organ located in the anterior portion of the ventral thoracic cavity, just behind the sternum. Because the thymus is the site of development of T lymphocytes (T cells), it is frequently targeted in research studies that involve the immune system. Furthermore, the rapid expansion of transgenic and gene-targeted mouse models of immune disorders has enabled a concomitant increase in the number of studies of T-cell development. Such studies may require the administration of intrathymic injections, which have traditionally been done using a surgical approach. Surgical manipulation can result in pain or distress to the animal, which may affect the immune system, potentially confounding experimental results. Here, the authors describe a nonsurgical, ultrasound-guided approach for intrathymic injection in the mouse that results in negligible distress to the animal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.