GuidelinePancreas2010
The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer.
Guideline in Pancreas, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05702944 (A Pilot Study for Randomized Controlled Trial on the Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma), which is not on this map. Cited by 216 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study for Randomized Controlled Trial on the Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma
Who cites it
216 citing papers in PubMed, 4 syntheses or guidelines pooled it, 582 citations in OpenAlex.
- Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochromocytomas and paragangliomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Guideline
- Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.The oncologist · 2016Pooled it
- Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.Thyroid : official journal of the American Thyroid Association · 2015Guideline
- Guideline
- Calcified liver metastases from medullary thyroid carcinoma in a Multiple Endocrine Neoplasia Type 2A patient.Radiology case reports · 2026Article
- Learning curve of blood pressure management during phaeochromocytoma surgery without preoperative alpha-blockade dose escalation.Endocrine connections · 2026Article
- The unseen storm: Intraoperative catecholamine crisis revealing a silent bladder paraganglioma.Urology case reports · 2026Article
- Ectopic ACTH syndrome caused by pheochromocytoma: diagnostic challenges and surgical outcomes in two cases.BMC endocrine disorders · 2026Article
- Article
- Paraganglioma and cardiomyopathy leading to cardiogenic shock: a case report.ESC heart failure · 2026Article
- Paraganglioma of the urinary bladder: A case report and discussion of the literature.Urology case reports · 2026Article
- Seasonal and Climatic Influences on Catecholamine Metabolite Levels in Patients With and Without Pheochromocytoma-Paraganglioma.Diagnostics (Basel, Switzerland) · 2026Article
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Pheochromocytoma presenting as suspected peripartum cardiomyopathy with ventricular tachyarrhythmias.HeartRhythm case reports · 2025Article
- Adrenal causes of endocrine hypertension in childhood or adolescence.Journal of endocrinological investigation · 2025Review
- Clinical parameters-based machine learning models for predicting intraoperative hemodynamic instability in hypertensive pheochromocytomas and paragangliomas patients.World journal of urology · 2025Article
- Article
- Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer.NPJ precision oncology · 2025Article
- Clinicopathological and genomic analysis of pediatric pheochromocytoma and sympathetic paraganglioma.Endocrine journal · 2025Article
156 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Pheochromocytomas, intra-adrenal paraganglioma, and extra-adrenal sympathetic and parasympathetic paragangliomas are neuroendocrine tumors derived from adrenal chromaffin cells or similar cells in extra-adrenal sympathetic and parasympathetic paraganglia, respectively. Serious morbidity and mortality rates associated with these tumors are related to the potent effects of catecholamines on various organs, especially those of the cardiovascular system. Before any surgical procedure is done, preoperative blockade is necessary to protect the patient against significant release of catecholamines due to anesthesia and surgical manipulation of the tumor. Treatment options vary with the extent of the disease, with laparoscopic surgery being the preferred treatment for removal of primary tumors. Medullary thyroid cancer (MTC) is a malignancy of the thyroid C cells or parafollicular cells. Thyroid C cells elaborate a number of peptides and hormones, such as calcitonin, carcinoembryonic antigen, and chromogranin A. Some or all of these markers are elevated in patients with MTC and can be used to confirm the diagnosis as well as to follow patients longitudinally for recurrence. Medullary thyroid cancer consists of a spectrum of diseases that ranges from extremely indolent tumors that are stable for many years to aggressive types associated with a high mortality rate. Genetic testing for RET mutations has allowed identification of familial cases and prophylactic thyroidectomy for cure. The only curative treatment is complete surgical resection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.