Evidence map›Paper›PMID 20664082›Full record

ReviewPhysiological reviews2010

Neurophysiological and computational principles of cortical rhythms in cognition.

Xiao-Jing Wang

Registry-linked trialAbstract readReview
In one paragraph

Review in Physiological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03828734 (Modulation of Alpha and Theta Oscillations in a Cognitive Control Retrospective Cue Task With Frequency Specific Rhythmic Transcranial Magnetic Stimulation), which is not on this map. Cited by 875 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
875citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03828734 nacompletednot on this mapstarted 2019, after this paper: background citation

Modulation of Alpha and Theta Oscillations in a Cognitive Control Retrospective Cue Task With Frequency Specific Rhythmic Transcranial Magnetic Stimulation

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2019Enrolled58ConditionsExecutive FunctionArmsTheta TMS, Alpha TMS, Arrhythmic TMS
3 · Its place in the literature

Who cites it

875 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Spectral dependence as a framework for neural coordination.Current research in neurobiology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Revisiting alpha-theta cross-frequency dynamics during working memory.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  19. Article
  20. Article

815 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Xiao-Jing WangDepartment of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA. xjwang@yale.edu

Funding

Recurrent Neual Circuit Basis of Time Integration and Decision MakingR01MH062349 · NIMH · YALE UNIVERSITY · PI WANG, XIAO-JING · 2001 to 2022
$7.2M
NIMH NIH HHS 2-R01-MH-62349NIMH NIH HHS R01 MH062349
6 · The paper itself

Abstract

Synchronous rhythms represent a core mechanism for sculpting temporal coordination of neural activity in the brain-wide network. This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving conditions. Over the last two decades, experimental and modeling work has made great strides in elucidating the detailed cellular and circuit basis of these rhythms, particularly gamma and theta rhythms. The underlying physiological mechanisms are diverse (ranging from resonance and pacemaker properties of single cells to multiple scenarios for population synchronization and wave propagation), but also exhibit unifying principles. A major conceptual advance was the realization that synaptic inhibition plays a fundamental role in rhythmogenesis, either in an interneuronal network or in a reciprocal excitatory-inhibitory loop. Computational functions of synchronous oscillations in cognition are still a matter of debate among systems neuroscientists, in part because the notion of regular oscillation seems to contradict the common observation that spiking discharges of individual neurons in the cortex are highly stochastic and far from being clocklike. However, recent findings have led to a framework that goes beyond the conventional theory of coupled oscillators and reconciles the apparent dichotomy between irregular single neuron activity and field potential oscillations. From this perspective, a plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention. Finally, implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.

Indexed as

AnimalsCerebral CortexCognitionComputational BiologyCortical SynchronizationElectroencephalographyMental DisordersNerve NetNeuronsOscillometryTheta Rhythm

Identifiers

PMID20664082
PMCPMC2923921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.