Evidence map›Paper›PMID 20664019›Full record

Trial reportDiabetes care2010

Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes.

Mariana Lazo, Steven F Solga, Alena Horska, Susanne Bonekamp, Anna Mae Diehl, Frederick L Brancati, Lynne E Wagenknecht, F Xavier Pi-Sunyer, Steven E Kahn, Jeanne M Clark and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618626 (Cardiovascular Diseases), which is not on this map. Cited by 166 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 12 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05618626 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2021 to 2025Enrolled300ConditionsNon-Alcoholic Fatty Liver Disease, Gallstone DiseaseArmsPhysical exercise and dietary intervention for NAFLD
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 12 syntheses or guidelines pooled it, 360 citations in OpenAlex.

  1. Guideline
  2. Prevention, surveillance, and early detection of hepatocellular carcinoma - a Brazilian multidisciplinary consensus.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026
    Guideline
  3. Pooled it
  4. Obesity in South and Southeast Asia-A new consensus on care and management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Guideline
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019
    Guideline
  9. Pooled it
  10. Guideline
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Comprehensive lifestyle interventionWorld journal of gastroenterology · 2019
    Trial
  20. Trial

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Mariana LazoJohns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland, USA. mlazo@jhsph.edu
Steven F Solga
Alena Horska
Susanne Bonekamp
Anna Mae Diehl
Frederick L Brancati
Lynne E Wagenknecht
F Xavier Pi-Sunyer
Steven E Kahn
Jeanne M Clark
Fatty Liver Subgroup of the Look AHEAD Research Group
Johns Hopkins Medicine · USJohns Hopkins University · USColumbia University · USDuke Medical Center · USUniversity of Washington · USWake Forest University · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FLEXNER, CHARLES W. · 1985 to 2007
$37.3M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057149 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 1999 to 2020
$17.4M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI AHIMA, REXFORD S. · 2013 to 2017
$9.7M
Fatty Liver Disease and Hepatic Energy Homostatis in SH*R01DK060427 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 2001 to 2005
$1.8M
NCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR-00052NIDDK NIH HHS P30 DK079637NIDDK NIH HHS R01 DK060427NIDDK NIH HHS R01-DK-060427NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01-DK-57149
6 · The paper itself

Abstract

objectiveWeight loss through lifestyle changes is recommended for nonalcoholic fatty liver disease (NAFLD). However, its efficacy in patients with type 2 diabetes is unproven. RESEARCH DESIGN AND

methodsLook AHEAD (Action for Health in Diabetes) is a 16-center clinical trial with 5,145 overweight or obese adults with type 2 diabetes, who were randomly assigned to an intensive lifestyle intervention (ILI) to induce a minimum weight loss of 7% or a control group who received diabetes support and education (DSE). In the Fatty Liver Ancillary Study, 96 participants completed proton magnetic resonance spectroscopy to quantify hepatic steatosis and tests to exclude other causes of liver disease at baseline and 12 months. We defined steatosis >5.5% as NAFLD.

resultsParticipants were 49% women and 68% white. The mean age was 61 years, mean BMI was 35 kg/m(2), mean steatosis was 8.0%, and mean aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were 20.5 and 24.2 units/l, respectively. After 12 months, participants assigned to ILI (n = 46) lost more weight (-8.5 vs. -0.05%; P < 0.01) than those assigned to DSE and had a greater decline in steatosis (-50.8 vs. -22.8%; P = 0.04) and in A1C (-0.7 vs. -0.2%; P = 0.04). There were no significant 12-month changes in AST or ALT levels. At 12 months, 26% of DSE participants and 3% (1 of 31) of ILI participants without NAFLD at baseline developed NAFLD (P < 0.05).

conclusionsA 12-month intensive lifestyle intervention in patients with type 2 diabetes reduces steatosis and incident NAFLD.

Indexed as

Life StyleAgedBody Mass IndexDiabetes Mellitus, Type 2Fatty LiverFemaleHumansMaleMiddle AgedWeight Loss

Identifiers

PMID20664019
PMCPMC2945152
OpenAlexW2086657936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.