ArticleFertility and sterility2011
Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer.
Article in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 7 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions.International journal of molecular sciences · 2025Pooled it
- Fresh versus frozen embryo transfers in assisted reproduction.The Cochrane database of systematic reviews · 2021Pooled it
- Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?BMC pregnancy and childbirth · 2020Pooled it
- Risk of gestational diabetes mellitus in women achieving singleton pregnancy spontaneously or after ART: a systematic review and meta-analysis.Human reproduction update · 2020Pooled it
- Fresh embryos versus freeze-all embryos - transfer strategies: Nuances of a meta-analysis.JBRA assisted reproduction · 2017Pooled it
- Risk of adverse pregnancy and perinatal outcomes after high technology infertility treatment: a comprehensive systematic review.Reproductive biology and endocrinology : RB&E · 2016Pooled it
- Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2016Pooled it
- Trial
- Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium.Journal of assisted reproduction and genetics · 2016Trial
- Factors influencing the birth weight of ART-conceived offspring.Journal of assisted reproduction and genetics · 2025Review
- Effect of ART treatments on maternal and neonatal outcomes in singleton live births: A large-scale retrospective cohort study.Heliyon · 2024Article
- Article
- Embryo cryopreservation leads to sex-specific DNA methylation perturbations in both human and mouse placentas.Human molecular genetics · 2022Article
- Placental Volume and Uterine Artery Doppler in Pregnancy Following In Vitro Fertilization: A Comprehensive Literature Review.Journal of clinical medicine · 2022Review
- Pregnancy outcomes following in vitro fertilization using fresh or frozen embryo transfer.JBRA assisted reproduction · 2021Article
- Luteal Support with very Low Daily Dose of Human Chorionic Gonadotropin after Fresh Embryo Transfer as an Alternative to Cycle Segmentation for High Responders Patients Undergoing Gonadotropin-Releasing Hormone Agonist-Triggered IVF.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Application of a Nomogram for Predicting the Risk of Subchorionic Hematoma in Early Pregnancy With In Vitro Fertilization-Embryo Transfer/Frozen Embryo Transfer.Frontiers in endocrinology · 2021Article
- Timing of exposure to gonadotropins has differential effects on the conceptus: evidence from a mouse model†.Biology of reproduction · 2020Article
- Observational
- Higher efficiency of frozen embryo transfer in male infertility cases in in vitro fertilization.Turkish journal of urology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis.
designRetrospective cohort study.
settingUniversity-based infertility center, January 1998 to June 2006. PATIENT(S): Two hundred eighteen IVF pregnancies after fresh embryo transfer (ET); 122 IVF pregnancies after frozen ET. INTERVENTION(S): Assessment of perinatal outcome in fresh versus frozen ET pregnancies. MAIN OUTCOME MEASURE(S): Pregnancy outcomes after fresh versus frozen embryo transfer (ET). Primary outcome was a composite of three events: preterm delivery, intrauterine growth restriction, or low birth weight. Secondary outcomes were subtypes of pregnancy loss. Associations were assessed using multivariate logistic regression. RESULT(S): The final sample included 340 pregnancies: 218 fresh and 122 frozen ETs. Singleton pregnancy was less likely after transfer of fresh embryos (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.23-0.67), and pregnancies after fresh ET were more likely to end in first-trimester loss (OR 1.82, 95% CI 1.05-3.13). Composite adverse outcome after transfer of fresh (44.0%) versus frozen (32.6%) embryos was higher (OR 1.52, 95% CI 0.90-2.56) and was strongly associated with twin gestation (OR 23.82, 95% CI 11.16-50.82). CONCLUSION(S): Perinatal morbidity is higher in IVF pregnancies conceived after a fresh ET compared with a frozen ET. Although some differences are related to conception with twin gestations, these findings suggest that adverse outcomes may be related to differences in IVF procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.