ArticleGenome biology2010
Paternally biased X inactivation in mouse neonatal brain.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Influence of Gonadal and Chromosomal Sex on the Brain Transcriptome in a Mouse Species with Natural Sex Reversal.Molecular biology and evolution · 2025Article
- Sex mechanisms as nonbinary influences on cognitive diversity.Hormones and behavior · 2024Review
- Distributed X chromosome inactivation in brain circuitry is associated with X-linked disease penetrance of behavior.Cell reports · 2024Article
- Epigenetic mechanisms regulate sex-specific bias in disease manifestations.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Article
- FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner.Neurobiology of disease · 2021Article
- Review
- Pervasive Inter-Individual Variation in Allele-Specific Expression in Monozygotic Twins.Frontiers in genetics · 2019Article
- Epigenetic and Cellular Diversity in the Brain through Allele-Specific Effects.Trends in neurosciences · 2018Review
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids.Scientific reports · 2017Article
- The level and distribution pattern of HP1β in the embryonic brain correspond to those of H3K9me1/me2 but not of H3K9me3.Histochemistry and cell biology · 2016Article
- Evolution of vertebrate sex chromosomes and dosage compensation.Nature reviews. Genetics · 2016Review
- Genetic differentiation of hypothalamus parentally biased transcripts in populations of the house mouse implicate the Prader-Willi syndrome imprinted region as a possible source of behavioral divergence.Molecular biology and evolution · 2014Article
- Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus.Journal of steroids & hormonal science · 2014Article
- Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus.Brain research · 2014Article
- The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?Cellular and molecular life sciences : CMLS · 2014Review
- Known unknowns for allele-specific expression and genomic imprinting effects.F1000prime reports · 2014Review
- Sex-differential selection and the evolution of X inactivation strategies.PLoS genetics · 2013Article
- Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The origin and evolution of genomic imprinting and viviparity in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundX inactivation in female eutherian mammals has long been considered to occur at random in embryonic and postnatal tissues. Methods for scoring allele-specific differential expression with a high degree of accuracy have recently motivated a quantitative reassessment of the randomness of X inactivation.
resultsAfter RNA-seq data revealed what appeared to be a chromosome-wide bias toward under-expression of paternal alleles in mouse tissue, we applied pyrosequencing to mouse brain cDNA samples from reciprocal cross F1 progeny of divergent strains and found a small but consistent and highly statistically significant excess tendency to under-express the paternal X chromosome.
conclusionsThe bias toward paternal X inactivation is reminiscent of marsupials (and extraembryonic tissues in eutherians), suggesting that there may be retained an evolutionarily conserved epigenetic mark driving the bias. Allelic bias in expression is also influenced by the sampling effect of X inactivation and by cis-acting regulatory variation (eQTL), and for each gene we quantify the contributions of these effects in two different mouse strain combinations while controlling for variability in Xce alleles. In addition, we propose an efficient method to identify and confirm genes that escape X inactivation in normal mice by directly comparing the allele-specific expression ratio profile of multiple X-linked genes in multiple individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.