ArticleNeural development2010
Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα.
Article in Neural development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Thyroid hormone as a temporal switch in mouse development.European thyroid journal · 2023Review
- RAR-related orphan receptor alpha and the staggerer mice: a fine molecular story.Frontiers in endocrinology · 2023Review
- In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.Stem cells international · 2023Article
- An Atlas of Thyroid Hormone Receptors' Target Genes in Mouse Tissues.International journal of molecular sciences · 2022Article
- Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis.Frontiers in endocrinology · 2022Article
- Altered Gene Expression of Thyroid Hormone Transporters and Deiodinases in iPS MeCP2-Knockout Cells-Derived Neurons.Molecular neurobiology · 2019Article
- The Role of Maternal Thyroid Hormones in Avian Embryonic Development.Frontiers in endocrinology · 2019Review
- Dendritic Self-Avoidance and Morphological Development of Cerebellar Purkinje Cells.Cerebellum (London, England) · 2018Review
- Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis.Scientific reports · 2017Article
- Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells.Frontiers in cellular neuroscience · 2017Article
- Morphological Plasticity of Emerging Purkinje Cells in Response to Exogenous VEGF.Frontiers in molecular neuroscience · 2017Article
- Deletion of the GluRδ2 Receptor in the Hotfoot Mouse Mutant Causes Granule Cell Loss, Delayed Purkinje Cell Death, and Reductions in Purkinje Cell Dendritic Tree Area.Cerebellum (London, England) · 2016Article
- Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.Scientific reports · 2015Article
- Deciphering direct and indirect influence of thyroid hormone with mouse genetics.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research.Frontiers in systems neuroscience · 2013Article
- Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and krüppel-like factor 9 in Purkinje cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?Frontiers in neuroanatomy · 2012Article
- Thyroid hormone action in cerebellum and cerebral cortex development.Journal of thyroid research · 2011Article
- Calcitonin gene-related peptide (CGRP) stimulates purkinje cell dendrite growth in culture.Neurochemical research · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe active form (T3) of thyroid hormone (TH) controls critical aspects of cerebellar development, such as migration of postmitotic neurons and terminal dendritic differentiation of Purkinje cells. The effects of T3 on early dendritic differentiation are poorly understood.
resultsIn this study, we have analyzed the influence of T3 on the progression of the early steps of Purkinje cell dendritic differentiation in postnatal day 0 organotypic cerebellar cultures. These steps include, successively, regression of immature neuritic processes, a stellate cell stage, and the extension of several long and mature perisomatic protrusions before the growth of the ultimate dendritic tree. We also studied the involvement of RORalpha, a nuclear receptor controlling early Purkinje cell dendritic differentiation. We show that T3 treatment leads to an accelerated progression of the early steps of dendritic differentiation in culture, together with an increased expression of RORalpha (mRNA and protein) in both Purkinje cells and interneurons. Finally, we show that T3 failed to promote early dendritic differentiation in staggerer RORalpha-deficient Purkinje cells.
conclusionsOur results demonstrate that T3 action on the early Purkinje cell dendritic differentiation process is mediated by RORalpha.
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