ArticleNutrition and cancer2010
Associations of red meat, fat, and protein intake with distal colorectal cancer risk.
Article in Nutrition and cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Dietary intake and tissue biomarkers of omega-6 fatty acids and risk of colorectal cancer in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.Nutrition & diabetes · 2025Pooled it
- Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2018Pooled it
- The association between dietary protein intake and colorectal cancer risk: a meta-analysis.World journal of surgical oncology · 2017Pooled it
- Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.PloS one · 2015Pooled it
- Processed and Unprocessed Red Meat and Risk of Colorectal Cancer: Analysis by Tumor Location and Modification by Time.PloS one · 2015Pooled it
- Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects.PloS one · 2012Trial
- Validation of a Colorectal Cancer Risk Prediction Model in US Black Women.Cancer prevention research (Philadelphia, Pa.) · 2026Article
- Dietary risk factors for colorectal cancer in Uganda: a case-control study.BMC nutrition · 2024Article
- A Prospective Analysis of Red and Processed Meat Intake in Relation to Colorectal Cancer in the Black Women's Health Study.The Journal of nutrition · 2022Article
- Association between dietary intake of fatty acids and colorectal cancer, a case-control study.Frontiers in nutrition · 2022Article
- The Mediterranean Diet as a Source of Natural Compounds: Does It Represent a Protective Choice against Cancer?Pharmaceuticals (Basel, Switzerland) · 2021Article
- Synergistic Effects of Genetic Variants of Glucose Homeostasis and Lifelong Exposures to Cigarette Smoking, Female Hormones, and Dietary Fat Intake on Primary Colorectal Cancer Development in African and Hispanic/Latino American Women.Frontiers in oncology · 2021Article
- Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota.Frontiers in cellular and infection microbiology · 2020Review
- Dual Behavior of Long-Chain Fatty Acids and Their Cyclooxygenase/Lipoxygenase Metabolites on Human Intestinal Caco-2 Cell Growth.Frontiers in pharmacology · 2020Article
- Review
- Red meat and processed meat intake and risk of colorectal cancer: a population-based case-control study.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019Article
- Constructing personalized longitudinal holo'omes of colon cancer-prone humans and their modeling in flies and mice.Oncotarget · 2019Article
- N-acetyl transferase 2/environmental factors and their association as a modulating risk factor for sporadic colon and rectal cancer.Journal of clinical laboratory analysis · 2017Article
- The association of percentage energy from fat and colon cancer risk among members of the US military.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2015Article
- Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Studies have suggested that red and processed meat consumption elevate the risk of colon cancer; however, the relationship between red meat, as well as fat and protein, and distal colorectal cancer (CRC) specifically is not clear. We determined the risk of distal CRC associated with red and processed meat, fat, and protein intakes in Whites and African Americans. There were 945 cases (720 White, 225 African American) of distal CRC and 959 controls (800 White, 159 African American). We assessed dietary intake in the previous 12 mo. Multivariate logistic regression analyses were used to obtain odds ratios (OR) and 95% confidence intervals (95% CI). There was no association between total, saturated, or monounsaturated fat and distal CRC risk. In African Americans, the OR of distal CRC for the highest category of polyunsaturated fat intake was 0.28 (95% CI = 0.08-0.96). The percent of energy from protein was associated with a 47% risk reduction in Whites (Q4 OR = 0.53, 95% CI = 0.37-0.77). Red meat consumption in Whites was associated with a marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our results do not support the hypotheses that fat, protein, and red meat increase the risk of distal CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.