ReviewJournal of cardiovascular translational research2010
Our expanding view of platelet functions and its clinical implications.
Review in Journal of cardiovascular translational research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Platelet Induced Functional Alteration of CD4International journal of molecular sciences · 2020Article
- Article
- Relationships of handgrip strength with the presence of cerebral microbleeds and platelet count in older Japanese adults.Oncotarget · 2020Article
- Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study.Scientific reports · 2020Article
- Evaluation of the anti-inflammatory effect of an anti-platelet agent crinumin on carrageenan-induced paw oedema and granuloma tissue formation in rats.Inflammopharmacology · 2018Article
- GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis.Frontiers in medicine · 2018Review
- Frequency of single nucleotide platelet receptor gene polymorphism (P2Y12-i744T>C) in coronary artery disease patients among Tamilian population.Journal of community genetics · 2017Article
- Article
- Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.PloS one · 2016Article
- Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse.PloS one · 2015Article
- Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.The Journal of clinical investigation · 2014Article
- Can non-human primates serve as models for investigating dengue disease pathogenesis?Frontiers in microbiology · 2013Review
- Clinical implications of platelet-vessel interaction.Journal of cardiovascular translational research · 2013Review
- Influence of platelet reactivity on clinical outcome of patients with stable coronary artery disease.Journal of cardiovascular translational research · 2013Review
- Article
- Thrombosis, physical activity, and acute coronary syndromes.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Platelets: versatile modifiers of innate and adaptive immune responses to transplants.Current opinion in organ transplantation · 2011Review
- Plasma circulating nucleic acids levels increase according to the morbidity of Plasmodium vivax malaria.PloS one · 2011Article
- HIV and SIV Associated Thrombocytopenia: An Expanding Role for Platelets in the Pathogenesis of HIV.Drug discovery today. Disease mechanisms · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Platelets are the primary cell mediator of thrombosis. A deficiency of platelets can result in severe bleeding defects. "Overactive" platelets contribute to life-threatening outcomes in diseases such as heart attack, stroke, and cancer. The use of platelet inhibitors for thrombosis prevention must therefore seek a delicate balance between inhibiting platelet activation and an associated increased bleeding risk. There are currently few platelet inhibitors clinically available, making the search for novel anti-platelet drug targets a major research priority. Several newly identified pathways of platelet activation may hold hope in this area. In addition, important roles for platelets beyond hemostasis have been discovered. Platelets have recently been described as mediators of diverse inflammatory diseases such as arthritis, hepatitis, malaria, and atherosclerosis. This has heightened the need to broaden our understanding of platelet functions and platelet-derived inflammatory mediators. It has also heightened interest in a continued search for new platelet inhibitors and presents new opportunities for platelet inhibitors to be used in a wide array of disease treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.