Evidence map›Paper›PMID 20661776›Full record

ReviewMedical & biological engineering & computing2010

Biophotonic techniques for the study of malaria-infected red blood cells.

Jakob M A Mauritz, Alessandro Esposito, Teresa Tiffert, Jeremy N Skepper, Alice Warley, Young-Zoon Yoon, Pietro Cicuta, Virgilio L Lew, Jochen R Guck, Clemens F Kaminski

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical & biological engineering & computing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Frontiers in cellular and infection microbiology · 2022
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. A FRET sensor for non-invasive imaging of amyloid formation in vivo.Chemphyschem : a European journal of chemical physics and physical chemistry · 2011
    Article
  13. Micro and nanotechnology for biological and biomedical applications.Medical & biological engineering & computing · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jakob M A MauritzDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Alessandro Esposito
Teresa Tiffert
Jeremy N Skepper
Alice Warley
Young-Zoon Yoon
Pietro Cicuta
Virgilio L Lew
Jochen R Guck
Clemens F Kaminski
University of Cambridge · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEKing's College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E008542/1
6 · The paper itself

Abstract

Investigation of the homeostasis of red blood cells upon infection by Plasmodium falciparum poses complex experimental challenges. Changes in red cell shape, volume, protein, and ion balance are difficult to quantify. In this article, we review a wide range of optical techniques for quantitative measurements of critical homeostatic parameters in malaria-infected red blood cells. Fluorescence lifetime imaging and tomographic phase microscopy, quantitative deconvolution microscopy, and X-ray microanalysis, are used to measure haemoglobin concentration, cell volume, and ion contents. Atomic force microscopy is briefly reviewed in the context of these optical methodologies. We also describe how optical tweezers and optical stretchers can be usefully applied to empower basic malaria research to yield diagnostic information on cell compliance changes upon malaria infection. The combined application of these techniques sheds new light on the detailed mechanisms of malaria infection providing potential for new diagnostic or therapeutic approaches.

Indexed as

Diagnostic ImagingErythrocytesHost-Parasite InteractionsHumansMalaria, FalciparumMicromanipulationOptical TweezersPlasmodium falciparum

Identifiers

PMID20661776
OpenAlexW2107377252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.