ArticleInfection2010
Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993-2006.
Article in Infection, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Status and outlook of pulmonary tuberculosis coinfection.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- Neuromeningeal Cryptococcosis and Tuberculosis Coinfection in Bamako: A One-Year Case Series.Open forum infectious diseases · 2023Article
- Multiplex detection of meningitis and encephalitis pathogens: A study from laboratory to clinic.Frontiers in neurology · 2022Article
- Combined Pulmonary Tuberculosis with Pulmonary and Pleural Cryptococcosis in a Patient Receiving Ruxolitinib Therapy.Infection and drug resistance · 2021Article
- Tuberculosis in HIV-Associated Cryptococcal Meningitis is Associated with an Increased Risk of Death.Journal of clinical medicine · 2020Article
- Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults.Open forum infectious diseases · 2018Article
- Tuberculous peritonitis and pleurisy accompanied by pulmonary cryptococcosis: A case report.The Journal of international medical research · 2018Article
- Cryptococcal Pleuritis Presenting with Lymphocyte-predominant and High Levels of Adenosine Deaminase in Pleural Effusions Coincident with Pulmonary Tuberculosis.Internal medicine (Tokyo, Japan) · 2018Article
- Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016.Emerging microbes & infections · 2017Review
- Molecular epidemiology of cryptococcal genotype VNIc/ST5 in Siriraj Hospital, Thailand.PloS one · 2017Article
- Cryptococcosis and tuberculosis co-infection in mainland China.Emerging microbes & infections · 2016Article
- Concurrent cryptococcal meningitis and disseminated tuberculosis occurring in an immunocompetent male.BMJ case reports · 2016Article
- A Case of Disseminated Cryptococcal Infection and Concurrent Lung Tuberculosis in a Patient under Steroid Therapy for Interstitial Pneumonia.Case reports in pulmonology · 2015Article
- Comparison of clinical features in patients with persistent and nonpersistent cryptococcal meningitis: twelve years of clinical experience in four centers in China.CNS neuroscience & therapeutics · 2013Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human immunodeficiency virus (HIV) epidemic and increasing use of immunosuppressive agents have increased the prevalence of both cryptococcosis and tuberculosis (TB). However, the status of co-infection with both pathogens remains unknown.
methodsThis study retrospectively reviewed patient records of cryptococcosis and TB co-infection from 1993 to 2006. The temporal sequence of co-infection was defined as either concurrent or sequential. Data collected included patient demographics, HIV status, co-morbidities, clinical manifestations, treatment strategies, and outcome at 1-year follow-up.
resultsThere were 23 patients with cryptococcosis and TB co-infection, representing 5.4% of cryptococcosis or 0.6% of TB cases. Eleven (48%) patients were HIV-infected, and no underlying disease or immunocompromised state could be identified in six (26%) patients. Twelve (52%) patients presented with concurrent infection, but diagnosis of co-infection could be achieved simultaneously in only three (13%). Constitutional symptoms, particularly fever and weight loss, were the most common presenting symptoms, developing in more than two-thirds of the patients. The majority (83%) of the patients made a good recovery following dual antifungal and anti-TB therapy. There were three mortalities at the 1-year follow-up, which might be attributable to a delay in diagnosis and treatment of co-infection. The outcomes of HIV-infected and non-HIV-infected patients were not significantly different.
conclusionsCryptococcosis and TB co-infection, although rare, develops in both immunocompromised and healthy individuals. Early diagnosis and treatment may improve patient prognosis. There should be a high index of suspicion in order to achieve a timely diagnosis in a TB endemic area.
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