ArticleExperimental brain research2010
Reduced soma size of the M-neurons in the lateral geniculate nucleus following foetal alcohol exposure in non-human primates.
Article in Experimental brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Impact of Developmental Alcohol Exposure on the Thalamus.Advances in experimental medicine and biology · 2025Review
- Cell death in the lateral geniculate nucleus, and its possible relationship with nicotinic receptors and sudden infant death syndrome (SIDS).Molecular neurobiology · 2023Article
- Effects of Early Alcohol Exposure on Functional Organization and Microstructure of a Visual-Tactile Integrative Circuit.Alcoholism, clinical and experimental research · 2018Article
- Prenatal Alcohol Exposure Affects Progenitor Cell Numbers in Olfactory Bulbs and Dentate Gyrus of Vervet Monkeys.Brain sciences · 2016Article
- Hippocampal neuron populations are reduced in vervet monkeys with fetal alcohol exposure.Developmental psychobiology · 2015Article
- Scaling the primate lateral geniculate nucleus: niche and neurodevelopment in the regulation of magnocellular and parvocellular cell number and nucleus volume.The Journal of comparative neurology · 2014Article
- Standardized full-field electroretinography in the Green Monkey (Chlorocebus sabaeus).PloS one · 2014Article
- Effects of early postnatal alcohol exposure on the developing retinogeniculate projections in C57BL/6 mice.Alcohol (Fayetteville, N.Y.) · 2013Article
- Does moderate drinking harm the fetal brain? Insights from animal models.Trends in neurosciences · 2012Review
- Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder.Neuropsychology review · 2011Review
- Functional assessment of magno, parvo and konio-cellular pathways; current state and future clinical applications.Journal of ophthalmic & vision research · 2011Article
- Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visual impairment is commonly reported as a consequence of heavy prenatal ethanol exposure in humans. Children generally display characteristic cranio-facial dysmorphology and represent typical severe cases of foetal alcohol syndrome. Binge-like rodent model systems have concluded that third trimester equivalent ethanol exposure results in widespread apoptosis in the visual system from the retina to the visual cortex. Neither clinical nor animal studies address the consequences of more moderate prenatal ethanol exposure on the visual system. The current study uses a naturalistic and voluntary consumption approach in non-human primates (Chlorocebus sabeus) in order to more closely model prenatal ethanol consumption patterns in humans. Pregnant vervet monkeys voluntarily drank on average 2.418 +/- 0.296 g etoh/kg/day four times a week during the third trimester. Using unbiased stereology, we estimated the neuronal and glial population of the parvocellular (P) and magnocellular (M) layers of the lateral geniculate nucleus (LGN) following foetal alcohol exposure (FAE) in infant subjects. Layer volume and total number of neurons and glia in the LGN of the FAE subjects were not significantly different from age-matched control subjects. The M neuronal soma size of FAE subjects, however, was significantly reduced to resemble the size of the P-neurons. These results suggest that alterations at the level of morphology and anatomy of the M-neurons may lead to behavioural deficits associated with the integrity of the dorsal visual pathway.
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