Trial reportPsychopharmacology2010
Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.
Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopamine D2/3- and μ-opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity in Healthy Volunteers
Deep Brain Stimulation for Severe Obsessive Compulsive Disorder: Efficacy and Mechanisms of Ventral Striatum and Subthalamic Nucleus Targets
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Obsessive-compulsive symptoms in adolescents with major depressive disorder: prevalence, clinical correlates, and association with childhood trauma.BMC psychiatry · 2025Article
- Memory Functions in Obsessive-Compulsive Disorder.Brain sciences · 2025Review
- Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction.Brain and behavior · 2023Review
- The story of memory and executive functions in obsessive-compulsive disorder: a case-control study.Trends in psychiatry and psychotherapy · 2022Article
- Executive Functioning and Clinical Variables in Patients with Obsessive-Compulsive Disorder.Brain sciences · 2021Article
- A Computational Approach for the Assessment of Executive Functions in Patients with Obsessive-Compulsive Disorder.Journal of clinical medicine · 2019Article
- Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2019Article
- Impaired cognitive plasticity and goal-directed control in adolescent obsessive-compulsive disorder.Psychological medicine · 2018Article
- Shared and disorder-specific task-positive and default mode network dysfunctions during sustained attention in paediatric Attention-Deficit/Hyperactivity Disorder and obsessive/compulsive disorder.NeuroImage. Clinical · 2017Article
- Cognitive Dysfunction in Obsessive-Compulsive Disorder.Current psychiatry reports · 2016Review
- Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.Frontiers in psychiatry · 2016Review
- Effects of gender and executive function on visuospatial working memory in adult obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2015Article
- Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder.The American journal of psychiatry · 2015Article
- Evidence accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis.Clinical psychological science : a journal of the Association for Psychological Science · 2015Article
- Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Frontiers in psychiatry · 2015Review
- Assessing neurocognitive function in psychiatric disorders: a roadmap for enhancing consensus.Neurobiology of learning and memory · 2014Article
- Break in volition: a virtual reality study in patients with obsessive-compulsive disorder.Experimental brain research · 2013Article
- What checkers actually check: an eye tracking study of inhibitory control and working memory.PloS one · 2012Article
- The extended fronto-striatal model of obsessive compulsive disorder: convergence from event-related potentials, neuropsychology and neuroimaging.Frontiers in human neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
rationalePatients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well.
objectiveThe aim of the study was to evaluate learning and working memory in OCD and to determine the effects of dopaminergic manipulations on these capacities.
methodsVisuospatial associative memory and spatial and verbal working memory were examined in 18 nondepressed patients with OCD and 18 matched healthy controls. The study further investigated whether acute administration of dopamine D2/D3 receptor agonist and antagonist would differentially modulate cognition in OCD. Each participant underwent the cognitive battery three times in a randomized double-blind, placebo-controlled crossover design.
resultsSignificant impairments in patients compared with controls were noted on the Cambridge Neuropsychological Test Automated Battery (CANTAB) paired associates learning (PAL) and a measure of sustained attention (rapid visual information processing, RVIP) that persisted across all sessions, with deficient strategy in the CANTAB spatial working memory task in the first session alone. Although the dopamine D2/D3 agonist, pramipexole, led to poorer performance on the PAL and RVIP tasks, no differential effects were noted between the two groups. No significant effects were noted for the D2/D3 antagonist, amisulpride.
conclusionsThe results are consistent with a specific associative memory deficit in OCD that remained robust despite possible practice effects and compensatory strategies and point to abnormal medial temporal lobe involvement in OCD in addition to the previously implicated frontostriatal loops, with no clear evidence of D2 receptor mediation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.