ArticlePLoS genetics2010
Tinkering evolution of post-transcriptional RNA regulons: puf3p in fungi as an example.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development inFrontiers in fungal biology · 2025Article
- Fused in sarcoma (FUS) inhibits milk production efficiency in mammals.Nature communications · 2024Article
- Fusarium oxysporum f. sp.mBio · 2023Article
- Pumilio2 Promotes Growth of Mature Neurons.International journal of molecular sciences · 2021Article
- Mitochondrial Biogenesis Is Positively Regulated by Casein Kinase I Hrr25 Through Phosphorylation of Puf3 inGenetics · 2020Article
- Human protein-RNA interaction network is highly stable across mammals.BMC genomics · 2019Article
- A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.Molecular cell · 2019Article
- Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling.Current genetics · 2019Article
- Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution.Molecular biology and evolution · 2018Article
- RNA regulons in cancer and inflammation.Current opinion in genetics & development · 2018Review
- Clarifying results and prevailing models for the evolution of Puf proteins and their RNA targets.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Post-transcriptional gene regulation in the biology and virulence of Candida albicans.Cellular microbiology · 2016Review
- Morphotype-specific effector functions of Cryptococcus neoformans PUM1.Scientific reports · 2016Article
- Coordinated Evolution of Transcriptional and Post-Transcriptional Regulation for Mitochondrial Functions in Yeast Strains.PloS one · 2016Article
- Integration of Posttranscriptional Gene Networks into Metabolic Adaptation and Biofilm Maturation in Candida albicans.PLoS genetics · 2015Article
- Puf4 regulates both splicing and decay of HXL1 mRNA encoding the unfolded protein response transcription factor in Cryptococcus neoformans.Eukaryotic cell · 2015Article
- Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets.PLoS biology · 2015Article
- Coordinating expression of RNA binding proteins with their mRNA targets.Scientific reports · 2014Article
- Post-transcriptional RNA regulons affecting cell cycle and proliferation.Seminars in cell & developmental biology · 2014Review
- Morphotype transition and sexual reproduction are genetically associated in a ubiquitous environmental pathogen.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide studies of post-transcriptional mRNA regulation in model organisms indicate a "post-transcriptional RNA regulon" model, in which a set of functionally related genes is regulated by mRNA-binding RNAs or proteins. One well-studied post-transcriptional regulon by Puf3p functions in mitochondrial biogenesis in budding yeast. The evolution of the Puf3p regulon remains unclear because previous studies have shown functional divergence of Puf3p regulon targets among yeast, fruit fly, and humans. By analyzing evolutionary patterns of Puf3p and its targeted genes in forty-two sequenced fungi, we demonstrated that, although the Puf3p regulon is conserved among all of the studied fungi, the dedicated regulation of mitochondrial biogenesis by Puf3p emerged only in the Saccharomycotina clade. Moreover, the evolution of the Puf3p regulon was coupled with evolution of codon usage bias in down-regulating expression of genes that function in mitochondria in yeast species after genome duplication. Our results provide a scenario for how evolution like a tinker exploits pre-existing materials of a conserved post-transcriptional regulon to regulate gene expression for novel functional roles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.