Evidence map›Paper›PMID 20661411›Full record

ArticleInternational journal of clinical and experimental pathology2010

Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ.

Michael Christie, Laura Chin-Lenn, Monique M Watts, Alpha E Tsui, Malcolm R Buchanan

Open access · greenAbstract readCase Reports
In one paragraph

Article in International journal of clinical and experimental pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Neuroendocrine neoplasms of the breast: a review of literature.Virchows Archiv : an international journal of pathology · 2024
    Review
  2. Review
  3. Breast cancer with neuroendocrine differentiation: an update based on the latest WHO classification.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Review
  4. Neuroendocrine breast carcinoma: a rare but challenging entity.Medical oncology (Northwood, London, England) · 2020
    Review
  5. Review
  6. Article
  7. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael ChristieDepartment of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Victoria, Australia. Michael.christie@mh.org.au
Laura Chin-Lenn
Monique M Watts
Alpha E Tsui
Malcolm R Buchanan
The Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma of the breast with coexisting carcinoma in situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid transcription factor-1 (TTF-1) by immunohistochemistry. Expression of neuroendocrine markers and TTF-1 in the in situ component allowed a highly confident diagnosis of primary small cell carcinoma of the breast. To our knowledge there is only one previous report of TTF-1 expressing in situ carcinoma associated with a primary SmCC of the breast.

Indexed as

Biomarkers, TumorBreast NeoplasmsCarcinoma in SituCarcinoma, Small CellErythema NodosumFatal OutcomeFemaleHumansImmunohistochemistryMiddle AgedNuclear ProteinsPleural EffusionPositron-Emission TomographyThyroid Nuclear Factor 1Tomography, X-Ray ComputedTranscription FactorsBiomarkers, TumorNKX2-1 protein, humanNuclear ProteinsThyroid Nuclear Factor 1Transcription FactorsBreastCarcinoma in situNeuroendocrineSmall cell carcinomaThyroid transcription factor-1

Identifiers

PMID20661411
PMCPMC2907125
OpenAlexW1587502726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.