ArticleInternational journal of clinical and experimental pathology2010
Correlating array comparative genomic hybridization findings with histology and outcome in spitzoid melanocytic neoplasms.
Article in International journal of clinical and experimental pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Genome-wide copy number variations as molecular diagnostic tool for cutaneous intermediate melanocytic lesions: a systematic review and individual patient data meta-analysis.Virchows Archiv : an international journal of pathology · 2021Pooled it
- The Morpho-Molecular Landscape of Spitz Neoplasms.International journal of molecular sciences · 2022Review
- The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification.Frontiers in oncology · 2022Review
- DNA copy number changes correlate with clinical behavior in melanocytic neoplasms: proposal of an algorithmic approach.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Through the looking glass and what you find there: making sense of comparative genomic hybridization and fluorescence in situ hybridization for melanoma diagnosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Review
- Clinical features and outcomes of spitzoid proliferations in children and adolescents.The British journal of dermatology · 2019Article
- Comparison of melanoma gene expression score with histopathology, fluorescence in situ hybridization, and SNP array for the classification of melanocytic neoplasms.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Review of diagnostic, prognostic, and predictive biomarkers in melanoma.Clinical & experimental metastasis · 2018Review
- Pathology and genomics of pediatric melanoma: A critical reexamination and new insights.Pediatric blood & cancer · 2018Review
- Genomic Landscape of Spitzoid Neoplasms Impacting Patient Management.Frontiers in medicine · 2018Review
- A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Review
- The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Article
- Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions.The American journal of surgical pathology · 2015Article
- Simulants of Malignant Melanoma.Oncology reviews · 2015Review
- High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi: phosphorylated CSE1L for the discrimination between melanoma and benign nevi.International journal of clinical and experimental pathology · 2015Article
- Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.International journal of clinical and experimental pathology · 2014Article
- Controversies in the evaluation and management of atypical melanocytic proliferations in children, adolescents, and young adults.Journal of the National Comprehensive Cancer Network : JNCCN · 2013Article
- Metastatic PRAME-Expressing Juvenile Spitzoid Melanoma on the Buttock.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanocytic neoplasms with spitzoid features including spitz nevi, spitz tumors and spitzoid melanomas are commonly encountered in the practice of dermatopathology. Although many cases can be accurately diagnosed on the basis of morphology and histology, a significant number of cases may be difficult to accurately classify. Several studies have now shown that chromosomal copy number aberrations are typical of melanoma while present in only a small percent and to a limited degree in spitz nevi. In this study, we correlated the clinical, histologic and array CGH findings of 10 spiztoid melanocytic neoplasms. Our study shows that the clinical and histologic changes correlate well with the molecular findings by array CGH. Further that array CGH can be used to help classify and predict behavior of spitzoid melanocytic neoplasms. A limited variety of copy number aberrations including gains of 11p and much more rarely 7q may be seen in spitz nevi. Additionally in this report we present the first case of a typical spitz nevus with copy number gains involving both 7q and 11p. Conversely, melanomas with spitzoid features typically have multiple chromsomal copy number aberrations involving a variety of loci. A smaller number of chromosomal aberrations, possibly a single aberrant locus, may be present in spitz tumors, but their presence may predict more aggressive behavior.
Indexed as
Identifiers
20661407PMC2907121W135555115What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.