Evidence map›Paper›PMID 20661255›Full record

ReviewNature reviews. Genetics2010

The widespread regulation of microRNA biogenesis, function and decay.

Jacek Krol, Inga Loedige, Witold Filipowicz

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03740087 (Search for the Transfer of Bovine miRNA to Humans by Comparing the Omnivore Group With a Vegan Group After a Dietary Intervention), which is not on this map. Cited by 2,560 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,560citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03740087 nacompletednot on this mapstarted 2015, after this paper: background citation

Search for the Transfer of Bovine miRNA to Humans by Comparing the Omnivore Group With a Vegan Group After a Dietary Intervention

TypeinterventionalSponsorUniversidad Autonoma de Nuevo LeonRan2015 to 2016Enrolled29ConditionsVegan DietArmsOmnivorous diet, Vegan diet
3 · Its place in the literature

Who cites it

2,560 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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2,500 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacek KrolFriedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.
Inga Loedige
Witold Filipowicz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.

Indexed as

RNA StabilityAnimalsGene Expression RegulationHumansMicroRNAsMicroRNAs

Identifiers

PMID20661255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.