ArticleClinical neuropharmacology2010
Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha.
Article in Clinical neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- A systematic review of the association between fatigue and genetic polymorphisms.Brain, behavior, and immunity · 2017Pooled it
- Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Pooled it
- Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review.International journal of molecular sciences · 2016Pooled it
- Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.The American journal of clinical nutrition · 2013Trial
- The effects of genotype on inflammatory response in hippocampal progenitor cells: A computational approach.Brain, behavior, & immunity - health · 2021Article
- Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?Frontiers in molecular neuroscience · 2017Review
- The role of inflammation in suicidal behaviour.Acta psychiatrica Scandinavica · 2015Review
- Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth.Brain, behavior, and immunity · 2015Article
- Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study.Psychiatry research · 2014Article
- The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder.International journal of geriatric psychiatry · 2014Article
- Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.Integrative medicine (Encinitas, Calif.) · 2014Review
- Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids.Journal of psychosomatic research · 2013Article
- Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.Neuroscience · 2013Review
- Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6.Brain, behavior, and immunity · 2013Article
- Psychiatric clearance for patients started on interferon-alpha-based therapies.The American journal of psychiatry · 2013Article
- Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-α treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Chronic hepatitis C and antiviral treatment regimens: where can psychology contribute?Journal of consulting and clinical psychology · 2013Review
- Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: a 16-week prospective study.Journal of psychosomatic research · 2013Article
- The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).Molecular psychiatry · 2013Article
- Depression in Late-Life: a Focus on Prevention.Focus (American Psychiatric Publishing) · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveInflammatory cytokines may influence both labile anger and depression. Both psychiatric conditions can occur during interferon alfa-based treatments. Evidence also indicates a central nervous system role for tumor necrosis factor alpha (TNF-alpha), whose expression may be increased by interferon alfa. A polymorphism in the promoter region of TNF-alpha has been associated with various inflammatory illnesses. We therefore hypothesized that this TNF-alpha polymorphism would influence susceptibility to psychiatric symptoms during interferon alfa therapy.
methodsOne hundred five patients with hepatitis C, initially without active major depression (major depressive disorder), were treated with interferon alfa and then prospectively monitored using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, the Beck Depression Inventory II, the Anger Irritability and Assault Questionnaire, and circulating TNF-alpha levels. The A-308G polymorphism (rs1800629) was determined using the 5'-nuclease assay. Repeated-measure mixed-effect analyses compared changes in symptoms over time.
resultBeck Depression Inventory II score increased during interferon alfa therapy (F = 6.2; P < 0.001), with 27% developing MDD. The TNF-alpha A allele was associated with worsened labile anger (F = 2.5; P < 0.05) and fatigue (F = 2.9; P < 0.05) during treatment but not with major depression incidence (chi = 0.0; P = 0.99) or increased Beck Depression Inventory II (F = 1.2; P = 0.31). Labile anger was not predicted by the serotonin transporter polymorphism (F = 0.8; P = 0.59). DISCUSSION: During treatment with an exogenous cytokine, vulnerability to worsening labile anger-distinct from major depression-is associated with genetic variability in TNF-alpha. This has implications both for patients being treated with interferon alfa and our understanding of genetic vulnerability for different subtypes of dysphoric and mood disorders.
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