ArticleExperimental & molecular medicine2010
Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes.
Article in Experimental & molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents.Future medicinal chemistry · 2024Article
- Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones.Current issues in molecular biology · 2023Review
- Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish.BMB reports · 2023Article
- A dahlia flower extract has antidiabetic properties by improving insulin function in the brain.Life metabolism · 2023Article
- Efficacy of a Novel Herbal Formulation (F2) on the Management of Obesity:Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Integrating Ethnobotany, Phytochemistry, and Pharmacology ofFrontiers in pharmacology · 2021Review
- Probiotic mediated NF-κB regulation for prospective management of type 2 diabetes.Molecular biology reports · 2020Review
- Glucose-lowering effect ofFood science & nutrition · 2020Article
- Article
- Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice.Biomolecules & therapeutics · 2019Article
- Cytoprotective effect of flavonoid-induced autophagy on bisphosphonate mediated cell death in osteoblast.Journal of cellular biochemistry · 2018Article
- HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model.Oncotarget · 2018Article
- Sulfuretin Attenuates MPP⁺-Induced Neurotoxicity through Akt/GSK3β and ERK Signaling Pathways.International journal of molecular sciences · 2017Article
- Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells.Experimental and therapeutic medicine · 2016Article
- Sulfuretin induces osteoblast differentiation through activation of TGF-β signaling.Molecular and cellular biochemistry · 2015Article
- Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetes.Experimental & molecular medicine · 2015Article
- Novel urushiols with human immunodeficiency virus type 1 reverse transcriptase inhibitory activity from the leaves of Rhus verniciflua.Journal of natural medicines · 2015Article
- Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation.International journal of molecular sciences · 2014Article
- Integrating traditional medicine into modern inflammatory diseases care: multitargeting by Rhus verniciflua Stokes.Mediators of inflammation · 2014Review
- The efficacy of SPA0355 in protecting β cells in isolated pancreatic islets and in a murine experimental model of type 1 diabetes.Experimental & molecular medicine · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NF-kappaB activation has been implicated as a key signaling mechanism for pancreatic beta-cell damage. Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit the inflammatory response by suppressing the NF-kappaB pathway. Therefore, we isolated sulfuretin from Rhus verniciflua and evaluated if sulfuretin could inhibit cytokine- or streptozotocin-induced beta-cell damage. Rat insulinoma RINm5F cells and isolated rat islets were treated with IL-1 beta and IFN-gamma to induce cytotoxicity. Incubation of cells and islets with sulfuretin resulted in a significant reduction of cytokine-induced NF-gamma B activation and its downstream events, iNOS expression, and nitric oxide production. The cytotoxic effects of cytokines were completely abolished when cells or islets were pretreated with sulfuretin. The protective effect of sulfuretin was further demonstrated by normal insulin secretion of cytokine-treated islets in response to glucose. Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was further evidenced by immunohistochemical staining of islets. However, the diabetogenic effects of streptozotocin were completely prevented when mice were pretreated with sulfuretin. The anti-diabetogenic effects of sulfuretin were also mediated by suppression of NF-kappaB activation. Collectively, these results indicate that sulfuretin may have therapeutic value in preventing beta-cell damage.
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