Evidence map›Paper›PMID 20660864›Full record

SynthesisNeurology2010

Physical activities and future risk of Parkinson disease.

Q Xu, Y Park, X Huang, A Hollenbeck, A Blair, A Schatzkin, H Chen

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05854524 (Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease), which is not on this map. Cited by 155 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 8 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05854524 narecruitingnot on this mapstarted 2024, after this paper: background citation

Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease

TypeinterventionalSponsorUniversity of Nevada, Las VegasRan2024 to 2026Enrolled90ConditionsParkinson DiseaseArmsAerobic exercise
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 8 syntheses or guidelines pooled it, 322 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Review
  15. Article
  16. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Q XuEpidemiology Branch, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA.
Y Park
X Huang
A Hollenbeck
A Blair
A Schatzkin
H Chen
Penn State Milton S. Hershey Medical Center · US

Funding

Structural MRI marker(s) of Parkinson's Disease's ProgressionR01NS060722 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2009 to 2013
$2.9M
Prospective Studies of Diet and Cancer in the AARP CohortZ01CP010196 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHATZKIN, ARTHUR · 2008 to 2008
$1.5M
Prospective studies on Parkinson's diseaseZ01ES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2006 to 2008
$1.2M
Intramural NIH HHSNCI NIH HHS Z01 CP010196-02NIEHS NIH HHS Z01-ES-101986NINDS NIH HHS R01 NS060722
6 · The paper itself

Abstract

objectiveTo prospectively investigate the relationship between physical activity and Parkinson disease (PD).

methodsWe evaluated physical activity in relation to PD among 213,701 participants of the NIH-AARP Diet and Health Study cohort. Physical activities over 4 periods (ages 15-18, 19-29, and 35-39, and in the past 10 years) were noted in 1996-1997, and physician-diagnosed PD was reported on the 2004-2006 follow-up questionnaire. Only cases diagnosed after 2000 (n = 767) were included in the analyses.

resultsHigher levels of moderate to vigorous activities at ages 35-39 or in the past 10 years as reported in 1996-1997 were associated with lower PD occurrence after 2000 with significant dose-response relationships. The multivariate odds ratios (OR) between the highest vs the lowest levels were 0.62 (95% CI confidence interval [CI] 0.48-0.81, p for trend 0.005) for ages 35-39 and 0.65 (95% CI 0.51-0.83, p for trend 0.0001) for in the past 10 years. Further analyses showed that individuals with consistent and frequent participation in moderate to vigorous activities in both periods had approximately a 40% lower risk than those who were inactive in both periods. Moderate to vigorous activities at earlier ages or light activities were not associated with PD. Finally, the association between higher moderate to vigorous physical activities and lower PD risk was demonstrated in a metaanalysis of prospective studies.

conclusionsAlthough we cannot exclude the possibility that less participation in physical activity is an early marker of PD, epidemiologic evidence suggests that moderate to vigorous exercise may protect against PD.

Indexed as

Life StyleMotor ActivityParkinson DiseaseAdolescentAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsRisk Reduction BehaviorSurveys and QuestionnairesYoung Adult

Identifiers

PMID20660864
PMCPMC2918886
OpenAlexW1977750438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.