ArticleProceedings of the National Academy of Sciences of the United States of America2010
Syringyl lignin biosynthesis is directly regulated by a secondary cell wall master switch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 127 citations in OpenAlex.
- Transcriptomic and Metabolomic Analyses Reveal the Phenylpropanoid Metabolism Regulatory Network inLife (Basel, Switzerland) · 2026Article
- Integrated transcriptomic and metabolomic analysis reveals the regulatory role of lignin biosynthesis in raspberry (Rubus niveus) prickle development.BMC plant biology · 2026Article
- A Role for the Plastidial GPT2 Translocator in the Modulation of Lignin Biosynthesis.Plant, cell & environment · 2025Article
- Direct and indirect effects of multiplex genome editing of F5H and FAD2 in oil crop camelina.Plant biotechnology journal · 2025Article
- Genome-wide analysis of the laccase gene family in tossa jute (Frontiers in plant science · 2025Article
- Lignin nanoparticles in food packaging: a sustainable approach to material design and performance enhancement.Frontiers in nutrition · 2025Review
- Deciphering the intricate hierarchical gene regulatory network: unraveling multi-level regulation and modifications driving secondary cell wall formation.Horticulture research · 2024Article
- SCL14 Inhibits the Functions of the NAC043-MYB61 Signaling Cascade to Reduce the Lignin Content in AutotetraploidInternational journal of molecular sciences · 2023Article
- Role of morphological traits and cell wall components in imparting resistance to pink stem borer,Frontiers in plant science · 2023Article
- MdMYB52 regulates lignin biosynthesis upon the suberization process in apple.Frontiers in plant science · 2022Article
- Elucidating the multifunctional role of the cell wall components in the maize exploitation.BMC plant biology · 2021Article
- Enzyme Complexes of Ptr4CL and PtrHCT Modulate Co-enzyme A Ligation of Hydroxycinnamic Acids for Monolignol Biosynthesis inFrontiers in plant science · 2021Article
- BEL1-like Homeodomain Protein BLH6a Is a Negative Regulator ofFrontiers in plant science · 2021Article
- The sugarcane ShMYB78 transcription factor activates suberin biosynthesis in Nicotiana benthamiana.Plant molecular biology · 2020Article
- Comparative Analysis of the Lignification Process of Two Bamboo Shoots Stored at Room Temperature.Plants (Basel, Switzerland) · 2020Article
- The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.Journal of experimental botany · 2020Article
- Transcriptional and Post-transcriptional Regulation of Lignin Biosynthesis Pathway Genes inFrontiers in plant science · 2020Review
- PdWND3A, a wood-associated NAC domain-containing protein, affects lignin biosynthesis and composition in Populus.BMC plant biology · 2019Article
- Gene regulatory networks for lignin biosynthesis in switchgrass (Panicum virgatum).Plant biotechnology journal · 2019Article
- Transcriptome analysis highlights key differentially expressed genes involved in cellulose and lignin biosynthesis of sugarcane genotypes varying in fiber content.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin is a major component of plant secondary cell walls and is derived from p-hydroxyphenyl (H), guaiacyl (G), and syringyl (S) monolignols. Among higher plants, S lignin is generally considered to be restricted to angiosperms, which contain the S lignin-specific cytochrome P450-dependent monooxygenase, ferulic acid/coniferaldehyde/coniferyl alcohol 5-hydoxylase (F5H). The transcription factor MYB58 directly regulates expression of monolignol pathway genes except for F5H. Here we show that F5H expression is directly regulated by the secondary cell wall master switch NST1/SND1, which is known to regulate expression of MYB58. Deletion of NST1 expression in Medicago truncatula leads to a loss of S lignin associated with a more than 25-fold reduction of F5H expression but only around a 2-fold reduction in expression of other lignin pathway genes. A detailed phylogenetic analysis showed that gymnosperms lack both F5H and orthologs of NST1/SND1. We propose that both F5H and NST1 appeared at a similar time after the divergence of angiosperms and gymnosperms, with F5H possibly originating as a component of a defense mechanism that was recruited to cell wall biosynthesis through the evolution of NST1-binding elements in its promoter.
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