ArticleProceedings of the National Academy of Sciences of the United States of America2010
Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Genetic Structure and Selection Signals in Hetian Gray Donkeys and Xinjiang Donkeys from Xinjiang, China.Animals : an open access journal from MDPI · 2026Article
- Genome-wide association study of mature cow size traits in American Angus cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Binding to the Other Side: The AT-Hook DNA-Binding Domain Allows Nuclear Factors to Exploit the DNA Minor Groove.International journal of molecular sciences · 2024Review
- Polymorphism and pelvic organ prolapse: combining strict inclusion criteria and environmental risk factors as a good standard for further studies.Gynecology and pelvic medicine · 2024Article
- Association between the rs1036819 polymorphism of the ZFAT gene and pelvic organ prolapse: a case-control study.International urogynecology journal · 2023Article
- The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.Journal of cellular biochemistry · 2021Article
- ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis.Nucleic acids research · 2020Article
- Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.International urogynecology journal · 2020Article
- Comprehensive genome and transcriptome analyses reveal genetic relationship, selection signature, and transcriptome landscape of small-sized Korean native Jeju horse.Scientific reports · 2019Article
- Article
- Analysis of a large dataset reveals haplotypes carrying putatively recessive lethal and semi-lethal alleles with pleiotropic effects on economically important traits in beef cattle.Genetics, selection, evolution : GSE · 2019Article
- Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.International journal of molecular medicine · 2018Article
- A genome-wide association study for body weight in Japanese Thoroughbred racehorses clarifies candidate regions on chromosomes 3, 9, 15, and 18.Journal of equine science · 2017Article
- The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.The Journal of biological chemistry · 2016Article
- Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.Journal of structural and functional genomics · 2015Article
- Bioinformatic screening of autoimmune disease genes and protein structure prediction with FAMS for drug discovery.Protein and peptide letters · 2014Article
- Erythroid development in the mammalian embryo.Blood cells, molecules & diseases · 2013Review
- Article
- Pharmacogenomic update on multiple sclerosis: a focus on actual and new therapeutic strategies.The pharmacogenomics journal · 2012Review
- A genome-wide approach reveals novel imprinted genes expressed in the human placenta.Epigenetics · 2012Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TAL1 plays pivotal roles in vascular and hematopoietic developments through the complex with LMO2 and GATA1. Hemangioblasts, which have a differentiation potential for both endothelial and hematopoietic lineages, arise in the primitive streak and migrate into the yolk sac to form blood islands, where primitive hematopoiesis occurs. ZFAT (a zinc-finger gene in autoimmune thyroid disease susceptibility region/an immune-related transcriptional regulator containing 18 C(2)H(2)-type zinc-finger domains and one AT-hook) was originally identified as an immune-related transcriptional regulator containing 18 C(2)H(2)-type zinc-finger domains and one AT-hook, and is highly conserved among species. ZFAT is thought to be a critical transcription factor involved in immune-regulation and apoptosis; however, developmental roles for ZFAT remain unknown. Here we show that Zfat-deficient (Zfat(-/-)) mice are embryonic-lethal, with impaired differentiation of hematopoietic progenitor cells in blood islands, where ZFAT is exactly expressed. Expression levels of Tal1, Lmo2, and Gata1 in Zfat(-/-) yolk sacs are much reduced compared with those of wild-type mice, and ChIP-PCR analysis revealed that ZFAT binds promoter regions for these genes in vivo. Furthermore, profound reduction in TAL1, LMO2, and GATA1 protein expressions are observed in Zfat(-/-) blood islands. Taken together, these results suggest that ZFAT is indispensable for mouse embryonic development and functions as a critical transcription factor for primitive hematopoiesis through direct-regulation of Tal1, Lmo2, and Gata1. Elucidation of ZFAT functions in hematopoiesis might lead to a better understanding of transcriptional networks in differentiation and cellular programs of hematopoietic lineage and provide useful information for applied medicine in stem cell therapy.
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