ArticleProceedings of the National Academy of Sciences of the United States of America2010
Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Article
- Ruthenium Compounds Differentially Inhibit Group IA and IIA Snake Venom Phospholipase AInternational journal of molecular sciences · 2026Article
- Article
- Antivenom Administration After Rattlesnake Envenoming in Arizona Does Not Directly Diminish Pain.Toxins · 2024Article
- Article
- Using organ-on-a-chip technology to study haemorrhagic activities of snake venoms on endothelial tubules.Scientific reports · 2024Article
- Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies.Communications biology · 2024Review
- Viper Venom Phospholipase A2 Database: The Structural and Functional Anatomy of a Primary Toxin in Envenomation.Toxins · 2024Article
- Article
- What Are the Neurotoxins in Hemotoxic Snake Venoms?International journal of molecular sciences · 2023Review
- Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana.Scientific reports · 2022Article
- Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation.PLoS neglected tropical diseases · 2022Article
- The Enzymatic Core of Scorpion Venoms.Toxins · 2022Article
- Review of the Mechanisms of Snake Venom Induced Pain: It's All about Location, Location, Location.International journal of molecular sciences · 2022Review
- A general model for cell death and biomarker release from injured tissues.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase AScientific reports · 2019Article
- Organic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined.Toxins · 2018Article
- Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase AScientific reports · 2018Article
- Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major constituents of the venom of Bothrops asper, a deadly snake present in Latin America, induce the release of large amounts of K(+) and ATP from skeletal muscle. We also show that the released ATP amplifies the effect of the myotoxins, acting as a "danger signal," which spreads and causes further damage by acting on purinergic receptors. In addition, the release of ATP and K(+) well accounts for the pain reaction characteristic of these envenomations. As Bothrops asper myotoxins are representative of a large family of snake myotoxins with phospholipase A(2) structure, these findings are expected to be of general significance for snake bite envenomation. Moreover, they suggest potential therapeutic approaches for limiting the extent of muscle tissue damage based on antipurinergic drugs.
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