ArticleJournal of immunology (Baltimore, Md. : 1950)2010
TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- CytoVI: deep generative modeling of antibody-based single cell data.Nature methods · 2026Article
- Endothelial cell-released mitochondrial DNA promotes B cell differentiation and virus replication during severe fever with thrombocytopenia syndrome virus infection.Journal of virology · 2025Article
- CD27 is not an ideal marker for human memory B cells and can be modulated by IL-21 upon stimulated by Anti-CD40.Scientific reports · 2024Article
- CD62L expression marks a functionally distinct subset of memory B cells.Cell reports · 2023Article
- OMIP-095: 40-Color spectral flow cytometry delineates all major leukocyte populations in murine lymphoid tissues.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023Article
- Impaired tissue homing by the Ikzf3Frontiers in immunology · 2023Article
- Impacts of polyclonal antibody preparations from avian origin as a feed additive to beef cattle: immune responses during the step-up transition diets.Journal of animal science · 2021Article
- CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer's Patches.Scientific reports · 2020Article
- Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis.Scientific reports · 2019Article
- The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Follicular CD8Frontiers in immunology · 2017Review
- Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes.eLife · 2016Article
- CD21(-/low) B cells in human blood are memory cells.Clinical and experimental immunology · 2016Article
- L-selectin deficiency decreases aortic B1a and Breg subsets and promotes atherosclerosis.Thrombosis and haemostasis · 2014Article
- IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.PLoS pathogens · 2013Article
- Article
- Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge.Veterinary research · 2012Article
- Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
B cells recognize Ags on microorganisms both with their BCRs and TLRs. This innate recognition has the potential to alter the behavior of whole populations of B cells. We show in this study that in culture and in mice, MyD88-dependent activation of B cells via TLR2 or TLR9 causes the rapid loss of expression of CD62L by metalloproteinase-dependent shedding. Adoptive transfer of in vitro CpG-activated B cells showed them to be excluded from lymph nodes and Peyer's patches, but not the spleen. In vivo, both injection of CpG and systemic infection with Salmonella typhimurium caused the shedding of CD62L and the consequent focusing of B cell migration to the spleen and away from lymph nodes. We propose that wholesale TLR-mediated changes to B cell migration influence the development of immunity to pathogens carrying appropriate ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.