Evidence map›Paper›PMID 20660568›Full record

Trial reportThe Journal of physiology2010

Dosage-dependent non-linear effect of L-dopa on human motor cortex plasticity.

Katia Monte-Silva, David Liebetanz, Jessica Grundey, Walter Paulus, Michael A Nitsche

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Effects of acute ingestion of a pre-workout dietary supplement with and withoutJournal of the International Society of Sports Nutrition · 2017
    Trial
  17. Chronic Enhancement of Serotonin Facilitates Excitatory Transcranial Direct Current Stimulation-Induced Neuroplasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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  19. Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
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  20. Effect of serotonin on paired associative stimulation-induced plasticity in the human motor cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
    Trial

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katia Monte-SilvaDepartment of Clinical Neurophysiology, Georg- August-University Göttingen, Robert-Koch-Strasse 40, 37099 Göttingen, Germany.
David Liebetanz
Jessica Grundey
Walter Paulus
Michael A Nitsche

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuromodulator dopamine affects learning and memory formation and their likely physiological correlates, long-term depression and potentiation, in animals and humans. It is known from animal experiments that dopamine exerts a dosage-dependent, inverted U-shaped effect on these functions. However, this has not been explored in humans so far. In order to reveal a non-linear dose-dependent effect of dopamine on cortical plasticity in humans, we explored the impact of 25, 100 and 200 mg of L-dopa on transcranial direct current (tDCS)-induced plasticity in twelve healthy human subjects. The primary motor cortex served as a model system, and plasticity was monitored by motor evoked potential amplitudes elicited by transcranial magnetic stimulation. As compared to placebo medication, low and high dosages of L-dopa abolished facilitatory as well as inhibitory plasticity, whereas the medium dosage prolonged inhibitory plasticity, and turned facilitatory plasticity into inhibition. Thus the results show clear non-linear, dosage-dependent effects of dopamine on both facilitatory and inhibitory plasticity, and support the assumption of the importance of a specific dosage of dopamine optimally suited to improve plasticity. This might be important for the therapeutic application of dopaminergic agents, especially for rehabilitative purposes, and explain some opposing results in former studies.

Indexed as

AdultDopamine AgonistsDose-Response Relationship, DrugFemaleHumansLevodopaMaleMotor CortexNeuronal PlasticityTranscranial Magnetic StimulationDopamine AgonistsLevodopa

Identifiers

PMID20660568
PMCPMC2988508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.