ReviewThe Journal of physiology2010
Force and power generating mechanism(s) in active muscle as revealed from temperature perturbation studies.
Review in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Isometric slow- and fast-contracting skeletal muscle fibres have more similar cellular and molecular properties at 37°C than at 25°C in older adults.The Journal of physiology · 2026Article
- Theoretical treatment of tension transients in muscle following sudden changes in orthophosphate concentration: implications for energy transduction.Journal of muscle research and cell motility · 2025Article
- Validation of the energetics of a Huxley muscle-tendon complex model using experimental data obtained from mouse soleus muscle.The Journal of experimental biology · 2025Article
- Molecular Events of the Crossbridge Cycle Reflected in the Force-Velocity Relationship of Activated Muscle.Frontiers in physiology · 2022Review
- The Road to the Beijing Winter Olympics and Beyond: Opinions and Perspectives on Physiology and Innovation in Winter Sport.Journal of science in sport and exercise · 2021Review
- Exhaustion of Skeletal Muscle Fibers Within Seconds: Incorporating Phosphate Kinetics Into a Hill-Type Model.Frontiers in physiology · 2020Article
- Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and Myosin.Biophysical journal · 2018Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- Temperature Effects on Force and Actin⁻Myosin Interaction in Muscle: A Look Back on Some Experimental Findings.International journal of molecular sciences · 2018Review
- Phosphate increase during fatigue affects crossbridge kinetics in intact mouse muscle at physiological temperature.The Journal of physiology · 2017Article
- Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?Journal of muscle research and cell motility · 2016Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Power output of skinned skeletal muscle fibres from the cheetah (Acinonyx jubatus).The Journal of experimental biology · 2013Article
- Mechanism of force enhancement during and after lengthening of active muscle: a temperature dependence study.Journal of muscle research and cell motility · 2012Article
- Measuring mitochondrial respiration in intact single muscle fibers.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Force decline during fatigue is due to both a decrease in the force per individual cross-bridge and the number of cross-bridges.The Journal of physiology · 2011Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basic characteristics of the process of force and power generation in active muscle that have emerged from temperature studies are examined. This is done by reviewing complementary findings from temperature-dependence studies and rapid temperature-jump (T-jump) experiments and from intact and skinned fast mammalian muscle fibres. In isometric muscle, a small T-jump leads to a characteristic rise in force showing that crossbridge force generation is endothermic (heat absorbed) and associated with increased entropy (disorder). The sensitivity of the T-jump force generation to added inorganic phosphate (Pi) indicates that a T-jump enhances an early step in the actomyosin (crossbridge) ATPase cycle before Pi-release. During muscle lengthening when steady force is increased, the T-jump force generation is inhibited. Conversely, during shortening when steady force is decreased, the T-jump force generation is enhanced in a velocity-dependent manner, showing that T-jump force generation is strain sensitive. Within the temperature range of ∼5–35◦C, the temperature dependence of steady active force is sigmoidal both in isometric and in shortening muscle. However, in shortening muscle, the endothermic character of force generation becomes more pronounced with increased velocity and this can, at least partly, account for the marked increase with warming of the mechanical power output of active muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.