ReviewThe Journal of physiology2010
BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.
Review in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Kinetics and functional consequences of BK channels activation by N-type CaFrontiers in cellular neuroscience · 2024Article
- BK Channel Gating Mechanisms: Progresses Toward a Better Understanding of Variants Linked Neurological Diseases.Frontiers in physiology · 2021Review
- A BK channel-mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing.Science advances · 2018Article
- Ethanol Effect on BK Channels is Modulated by Magnesium.Alcoholism, clinical and experimental research · 2015Article
- Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels.Biomolecules · 2015Review
- Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.BMC neuroscience · 2015Article
- Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons.Neuropharmacology · 2015Article
- The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.PLoS neglected tropical diseases · 2015Article
- S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels.Frontiers in physiology · 2014Review
- Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S).Frontiers in physiology · 2014Article
- Lack of negative slope in I-V plots for BK channels at positive potentials in the absence of intracellular blockers.The Journal of general physiology · 2013Article
- Molecular mechanism of pharmacological activation of BK channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated.The Journal of general physiology · 2011Article
- A novel calcium binding site in the slow vacuolar cation channel TPC1 senses luminal calcium levels.The Plant cell · 2011Article
- Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.The Journal of biological chemistry · 2011Article
- A global synergy of ions and voltage?The Journal of physiology · 2010Article
- Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel.The Journal of general physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Ion channels and lipid phosphatases adopt a transmembrane voltage sensor domain (VSD) that moves in response to physiological variations of the membrane potential to control their activities. However, the VSD movements and coupling to the channel or phosphatase activities may differ depending on various interactions between the VSD and its host molecules. BK-type voltage, Ca²(+) and Mg²(+) activated K(+) channels contain the VSD and a large cytosolic domain (CTD) that binds Ca²(+)and Mg²(+). VSD movements are coupled to BK channel opening with a unique allosteric mechanism and are modulated by Ca²(+) and Mg²(+) binding via the interactions among the channel pore, VSD and CTD. These properties are energetically advantageous for the pore to be controlled by multiple stimuli, revealing the adaptability of the VSD to its host molecules and showing the potential for intracellular signals to affect the VSD in order to modulate the function of its host molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.