ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor.Developmental cell · 2022Article
- The role of altered protein acetylation in neurodegenerative disease.Frontiers in aging neuroscience · 2022Review
- Enhanced Nerve Regeneration by Exosomes Secreted by Adipose-Derived Stem Cells with or without FK506 Stimulation.International journal of molecular sciences · 2021Article
- Article
- Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases.Scientific reports · 2020Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The histone deacetylase HDAC1 positively regulates Notch signaling duringBiology open · 2018Article
- Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling.Mechanisms of development · 2016Article
- Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.Genes & development · 2014Article
- HDAC signaling in neuronal development and axon regeneration.Current opinion in neurobiology · 2014Review
- Dedifferentiation of neurons precedes tumor formation in Lola mutants.Developmental cell · 2014Article
- Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.Disease models & mechanisms · 2014Article
- Review
- Cell-intrinsic drivers of dendrite morphogenesis.Development (Cambridge, England) · 2013Review
- The SUMO protease Verloren regulates dendrite and axon targeting in olfactory projection neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting.Neural development · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Compared to the mechanisms of axon guidance, relatively little is known about the transcriptional control of dendrite guidance. The Drosophila olfactory system with its stereotyped organization provides an excellent model to study the transcriptional control of dendrite wiring specificity. Each projection neuron (PN) targets its dendrites to a specific glomerulus in the antennal lobe and its axon stereotypically to higher brain centers. Using a forward genetic screen, we identified a mutation in Rpd3 that disrupts PN targeting specificity. Rpd3 encodes a class I histone deacetylase (HDAC) homologous to mammalian HDAC1 and HDAC2. Rpd3(-/-) PN dendrites that normally target to a dorsolateral glomerulus mistarget to medial glomeruli in the antennal lobe, and axons exhibit a severe overbranching phenotype. These phenotypes can be rescued by postmitotic expression of Rpd3 but not HDAC3, the only other class I HDAC in Drosophila. Furthermore, disruption of the atypical homeodomain transcription factor Prospero (Pros) yields similar phenotypes, which can be rescued by Pros expression in postmitotic neurons. Strikingly, overexpression of Pros can suppress Rpd3(-/-) phenotypes. Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.