ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Discriminative auditory fear learning requires both tuned and nontuned auditory pathways to the amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Thalamic input to the lateral amygdala determines the temporal window of fear-memory association.Communications biology · 2025Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Thalamus sends information about arousal but not valence to the amygdala.Psychopharmacology · 2023Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- Heterogeneous associative plasticity in the auditory cortex induced by fear learning - novel insight into the classical conditioning paradigm.Physiological research · 2021Article
- Single cell plasticity and population coding stability in auditory thalamus upon associative learning.Nature communications · 2021Article
- Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation.Nature communications · 2021Article
- Sex differences in auditory fear discrimination are associated with altered medial prefrontal cortex function.Scientific reports · 2020Article
- Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory.Neurobiology of learning and memory · 2019Article
- Cue-dependent safety and fear learning in a discriminative auditory fear conditioning paradigm in the mouse.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Projection from the Amygdala to the Thalamic Reticular Nucleus Amplifies Cortical Sound Responses.Cell reports · 2019Article
- Modulation of fear generalization by the zona incerta.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- An Emergent Discriminative Learning Is Elicited During Multifrequency Testing.Frontiers in neuroscience · 2019Article
- Anterior Auditory Field Is Needed for Sound Categorization in Fear Conditioning Task of Adult Rat.Frontiers in neuroscience · 2019Article
- Septal and Hippocampal Neurons Contribute to Auditory Relay and Fear Conditioning.Frontiers in cellular neuroscience · 2018Article
- Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress.Hearing research · 2017Article
- Primary auditory cortex regulates threat memory specificity.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Sex differences in discriminating between cues predicting threat and safety.Neurobiology of learning and memory · 2016Article
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2 authors.
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Abstract
The auditory system has two parallel streams in the brain that have been implicated in auditory fear learning. The lemniscal stream has selective neurons that are tonotopically organized and is thought to be important for sound discrimination. The nonlemniscal stream has less selective neurons, which are not tonotopically organized, and is thought to be important for multimodal processing and for several forms of learning. Therefore, it has been hypothesized that the lemniscal, but not the nonlemniscal, pathway supports discriminative fear to auditory cues. To test this hypothesis we assessed the effect of electrolytic lesions to the ventral, or medial, division of the medial geniculate nucleus (MGv or MGm, which correspond, respectively, to the lemniscal and the nonlemniscal auditory pathway to amygdala) on the acquisition, expression and extinction of fear responses in discriminative auditory fear conditioning, where one tone is followed by shock (conditioned stimulus, CS(+)), and another is not (CS(-)). Here we show that with single-trial conditioning control, MGv- and MGm-lesioned male rats acquire nondiscriminative fear of both the CS(+) and the CS(-). However, after multiple-trial conditioning, control rats discriminate between the CS(+) and CS(-), whereas MGv- and MGm-lesioned do not. Furthermore, post-training lesions of MGm, but not MGv, lead to impaired expression of discriminative fear. Finally, MGm-lesioned rats display high levels of freezing to both the CS(+) and CS(-) even after an extinction session to the CS(+). In summary, our findings suggest that the lemniscal pathway is important for discriminative learning, whereas the nonlemniscal is important for negatively regulating fear responses.
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