Evidence map›Paper›PMID 20660212›Full record

ArticleJournal of clinical microbiology2010

Molecular epidemiological evaluation of the recent resurgence in mumps virus infections in Ireland.

Michael J Carr, Eibhlín Moss, Allison Waters, Jonathan Dean, Li Jin, Suzie Coughlan, Jeff Connell, William W Hall, Jaythoon Hassan

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04815811 (Study of the Sex Differences in Inflammatory Diseases in Children), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04815811 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Study of the Sex Differences in Inflammatory Diseases in Children

TypeinterventionalSponsorQueen Fabiola Children's University HospitalRan2019 to 2023Enrolled160ConditionsSex Differences in Immune Response, Acute Inflammatory Diseases in ChildrenArmsBlood collection, Stool collection
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael J CarrNational Virus Reference Laboratory, University College Dublin, Dublin 4, Ireland. michael.carr@ucd.ie
Eibhlín Moss
Allison Waters
Jonathan Dean
Li Jin
Suzie Coughlan
Jeff Connell
William W Hall
Jaythoon Hassan
University College Dublin · IESt. Vincent's University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mumps is a vaccine-preventable disease; however, outbreaks have been reported in a number of countries with childhood immunization programs, particularly among young adults at the tertiary stage of education. We have retrospectively investigated the epidemiological, virological, and serological factors associated with mumps cases identified in Ireland from 2004 to 2009. Genetic analysis of mumps virus strain variability demonstrated that a single genotype, genotype G, was circulating, and it was also detected in cerebrospinal fluid samples obtained from patients with meningitis. We observed that younger individuals were disproportionately affected with neurological sequelae following mumps virus infection, and the average age of patients with mumps virus RNA detected in cerebrospinal fluid was 19.25 years (median, 19 years; range, 14 to 24 years). Our analysis showed a 4-fold rise in mumps cases in 2008-2009 and an increased incidence in infection in those >or=30 years of age. Over a 6-year period (2004 to 2009), a total of 7,805 serum samples were investigated; of this number, 1,813 (23%) were positive for mumps virus-specific IgM. We observed a strong bias for acute mumps virus infection in males compared to females (P < 10(-32)) that was independent of vaccination status.

Indexed as

AdolescentAdultAge DistributionAntibodies, ViralCerebrospinal FluidChildChild, PreschoolCluster AnalysisFemaleGenotypeHumansImmunoglobulin MIncidenceInfantIrelandMaleAntibodies, ViralImmunoglobulin MRNA, Viral

Identifiers

PMID20660212
PMCPMC2937737
OpenAlexW2063016461

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.