ArticleJournal of virology2010
Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- A comprehensive overview of monkeypox virus disease.Tropical medicine and health · 2026Review
- Mpox virus: virology, molecular epidemiology, and global public health challenges.Frontiers in microbiology · 2025Review
- The prospective outcome of the monkeypox outbreak in 2022 and characterization of monkeypox disease immunobiology.Frontiers in cellular and infection microbiology · 2023Article
- Poxviruses and the immune system: Implications for monkeypox virus.International immunopharmacology · 2022Review
- Monkeypox: disease epidemiology, host immunity and clinical interventions.Nature reviews. Immunology · 2022Review
- Article
- Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Influenza infection fortifies local lymph nodes to promote lung-resident heterosubtypic immunity.The Journal of experimental medicine · 2021Article
- Batf3-Dependent Dendritic Cells Promote Optimal CD8 T Cell Responses against Respiratory Poxvirus Infection.Journal of virology · 2018Article
- Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection.Journal of virology · 2016Article
- The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision.The Journal of investigative dermatology · 2015Article
- Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.PLoS pathogens · 2015Article
- Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction.Nature communications · 2014Article
- New insights into the role of the aryl hydrocarbon receptor in the function of CD11c⁺ cells during respiratory viral infection.European journal of immunology · 2014Article
- Quantitative and qualitative deficits in neonatal lung-migratory dendritic cells impact the generation of the CD8+ T cell response.PLoS pathogens · 2014Article
- Paramyxovirus activation and inhibition of innate immune responses.Journal of molecular biology · 2013Review
- Viral infection of the lung: host response and sequelae.The Journal of allergy and clinical immunology · 2013Review
- Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains.Respiratory research · 2012Article
- CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.Journal of virology · 2012Article
- A STATus report on DC development.Journal of leukocyte biology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A large number of dendritic cell (DC) subsets have now been identified based on the expression of a distinct array of surface markers as well as differences in functional capabilities. More recently, the concept of unique subsets has been extended to the lung, although the functional capabilities of these subsets are only beginning to be explored. Of particular interest are respiratory DCs that express CD103. These cells line the airway and act as sentinels for pathogens that enter the lung, migrating to the draining lymph node, where they add to the already complex array of DC subsets present at this site. Here we assessed the contributions of these individual populations to the generation of a CD8(+) T-cell response following respiratory infection with poxvirus. We found that CD103(+) DCs were the most effective antigen-presenting cells (APC) for naive CD8(+) T-cell activation. Surprisingly, we found no evidence that lymph node-resident or parenchymal DCs could prime virus-specific cells. The increased efficacy of CD103(+) DCs was associated with the increased presence of viral antigen as well as high levels of maturation markers. Within the CD103(+) DCs, we observed a population that expressed CD8alpha. Interestingly, cells bearing CD8alpha were less competent for T-cell activation than their CD8alpha(-) counterparts. These data show that lung-migrating CD103(+) DCs are the major contributors to CD8(+) T-cell activation following poxvirus infection. However, the functional capabilities of cells within this population differ with the expression of CD8, suggesting that CD103(+) cells may be divided further into distinct subsets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.