ReviewExperimental biology and medicine (Maywood, N.J.)2010
Vitamin D and host resistance to infection? Putting the cart in front of the horse.
Review in Experimental biology and medicine (Maywood, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review.Frontiers in nutrition · 2025Pooled it
- 25(OH)vitamin D inflammatory and oxidative stress markers in healthy Holstein cows and cows with peri-partum diseases during the transition period.Scientific reports · 2025Article
- Review
- Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy.European journal of medicinal chemistry · 2022Review
- Vitamin D and COVID-19: is there a role?Journal of diabetes and metabolic disorders · 2021Review
- Article
- Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a ClinicalFrontiers in immunology · 2019Article
- Vitamin D and Influenza-Prevention or Therapy?International journal of molecular sciences · 2018Review
- Dietary vitamin DNutrition & metabolism · 2018Article
- The role of UVR and vitamin D on T cells and inflammatory bowel disease.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2017Review
- Vitamin D and Lung Infection.Infection and immunity · 2016Article
- Protective links between vitamin D, inflammatory bowel disease and colon cancer.World journal of gastroenterology · 2016Review
- Vitamin D every day to keep the infection away?Nutrients · 2015Review
- Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?Nutrients · 2015Review
- Vitamin D inhibits the occurrence of experimental cerebral malaria in mice by suppressing the host inflammatory response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- How important is vitamin D in preventing infections?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Review
- Vitamin D: effects on childhood health and disease.Nature reviews. Endocrinology · 2013Review
- Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.Archives of biochemistry and biophysics · 2012Review
- Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin D is being touted as an anti-infective agent and it has even been suggested that vitamin D supplementation could be effective against the H1N1 influenza virus. The claims are largely based on the ability of vitamin D to induce antibacterial peptides and evidence that the immune system produces active vitamin D (1,25(OH)(2)D(3)) in situ. While there are many examples of immune production of 1,25(OH)(2)D(3) in vitro, there is little in vivo evidence. In addition, it is not clear what role immune production of 1,25(OH)(2)D(3) has on the course of disease. Vitamin D and 1,25(OH)(2)D(3) inhibit T helper type 1 (Th1)/Th17-mediated immune responses and autoimmune diseases by acting on the innate and acquired immune system to inhibit the function of Th1 and Th17 cells. Th1 and Th17 cells are important in host resistance to many infections including tuberculosis (TB) caused by Mycobacterium tuberculosis. Paradoxically the innate immune system is induced to produce antibacterial peptides that are effective against TB in vitro. Data from several models of infection have so far not supported a role for vitamin D in affecting the course of disease. There is also very little evidence that vitamin D affects the course of human TB infection. Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.