ArticleEndocrinology2010
Subfertility linked to combined luteal insufficiency and uterine progesterone resistance.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Molecular Shape-Preserving Au Electrode for Progesterone Detection.Sensors (Basel, Switzerland) · 2025Article
- Article
- Modeling Trophoblast Cell-Guided Uterine Spiral Artery Transformation in the Rat.International journal of molecular sciences · 2022Review
- Renal functional, transcriptome, and methylome adaptations in pregnant Sprague Dawley and Brown Norway rats.PloS one · 2022Article
- Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- Hemochorial placentation: development, function, and adaptations.Biology of reproduction · 2018Review
- Hypoxia and Placental Development.Birth defects research · 2017Review
- Origin of a rapidly evolving homeostatic control system programming testis function.The Journal of endocrinology · 2017Article
- Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.American journal of obstetrics and gynecology · 2016Article
- A Prolactin Family Paralog Regulates Placental Adaptations to a Physiological Stressor.Biology of reproduction · 2016Article
- Rethinking progesterone regulation of female reproductive cyclicity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neonatal Progesterone Programs Adult Uterine Responses to Progesterone and Susceptibility to Uterine Dysfunction.Endocrinology · 2015Article
- Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.The Journal of biological chemistry · 2014Article
- Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy.The International journal of developmental biology · 2014Review
- Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.PLoS genetics · 2013Article
- BMPR2 is required for postimplantation uterine function and pregnancy maintenance.The Journal of clinical investigation · 2013Article
- Evaluation of the toxicity of Pradosia huberi extract during the preimplantation in Wistar rats.BioMed research international · 2013Article
- Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface.Placenta · 2012Review
- Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence.PloS one · 2012Article
- Regulatory pathways controlling the endovascular invasive trophoblast cell lineage.The Journal of reproduction and development · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Early pregnancy loss is common and can be caused by a range of factors. The Brown Norway (BN) rat exhibits reproductive dysfunction characterized by small litter size and pregnancy failure and represents a model for investigating early pregnancy loss. In this study, we investigated the establishment of pregnancy in the BN rat and gained insight into mechanisms causing its subfertility. Early stages of BN uteroplacental organization are unique. The BN primordial placenta is restricted in its development and correlates with limited BN uterine decidual development. BN uterine decidua was shown to be both structurally and functionally distinct and correlated with decreased circulating progesterone (P4) levels. Ovarian anomalies were also apparent in BN rats and included decreased ovulation rates and decreased transcript levels for some steroidogenic enzymes. Attempts to rescue the BN uterine decidual phenotype with steroid hormone therapy were ineffective. BN uteri were shown to exhibit reduced responsiveness to P4 but not to 17beta-estradiol. P4 resistance was associated with decreased transcript levels for the P4 receptor (Pgr), a P4 receptor chaperone (Fkbp4), and P4 receptor coactivators (Ncoa1 and Ncoa2). In summary, the BN rat exhibits luteal insufficiency and uterine P4 resistance, which profoundly affects its ability to reproduce.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.