ArticleChemical senses2010
Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.
Article in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- The Impact of Taste Preference-Related Gene Polymorphisms on Alcohol Consumption Behavior: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Strong association between the 12q24 locus and sweet taste preference in the Japanese population revealed by genome-wide meta-analysis.Journal of human genetics · 2020Pooled it
- A Systematic Review of Taste Differences Among People With Eating Disorders.Biological research for nursing · 2020Pooled it
- New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.The American journal of clinical nutrition · 2019Pooled it
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- Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders.Nutrients · 2026Review
- Choosing sweeteners wisely-nutrigenetic study on childhood obesity.Nutrition & metabolism · 2025Article
- Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2025Article
- Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong-Mien speakers.BMC biology · 2024Article
- Understanding the determinants of sweet taste liking in the African and East Asian ancestry groups in the U.S.-A study protocol.PloS one · 2024Article
- Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans.PloS one · 2024Article
- Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. - A Study Protocol.Research square · 2023Article
- TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.Nutrients · 2022Observational
- Single Nucleotide Polymorphisms in Close Proximity to theNutrients · 2021Article
- Association study of taste preference: Analysis in the Lithuanian population.Food science & nutrition · 2021Article
- From receptors to the brain: Psychophysical clues to taste physiology.Current opinion in physiology · 2021Article
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.Experimental brain research · 2020Article
- Allelic Variation in Taste Genes Is Associated with Taste and Diet Preferences and Dental Caries.Nutrients · 2019Article
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4 authors at 2 institutions in 1 country.
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Abstract
Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African-American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10(-3) to 10(-4)), which encodes the taste-specific G(alpha) protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.