Trial reportThe Journal of clinical endocrinology and metabolism2010
Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.
Trial report in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.Human reproduction update · 2026Pooled it
- Diagnosis, management, and outcomes of drug-induced erythrocytosis: a systematic review.Blood advances · 2025Pooled it
- The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits.Scientific reports · 2024Pooled it
- The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation.Health technology assessment (Winchester, England) · 2024Pooled it
- Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.The Journal of clinical endocrinology and metabolism · 2020Trial
- Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials.Andrology · 2020Trial
- Effect of testosterone on hepcidin, ferroportin, ferritin and iron binding capacity in patients with hypogonadotropic hypogonadism and type 2 diabetes.Clinical endocrinology · 2016Trial
- Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone.American journal of physiology. Endocrinology and metabolism · 2014Trial
- Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Trial
- Article
- Review
- Factors associated with hemoglobin response to hydroxyurea in patients with sickle cell disease.Blood red cells & iron · 2026Article
- Physiological, Metabolic, and Mitochondrial Adaptations to a One-Week Endurance Training Camp in Recreational Athletes: An Observational Study.Sports (Basel, Switzerland) · 2026Article
- Blood Volume and Haemoglobin Mass in Relation to Fat-Free Mass and Aerobic Capacity in Elite Junior Rowers.Sports (Basel, Switzerland) · 2026Article
- Establishment and Temporal Validation of Next-Generation Reference Intervals for Routine Hematological Parameters Using Large-Scale Data.Diagnostics (Basel, Switzerland) · 2026Article
- Big data-driven establishment and bias comparison of serum ferritin reference intervals in Zhejiang Chinese adults using six algorithms.Scientific reports · 2026Article
- Drug-drug interactions between sex hormones and analgesics linked to thromboembolic events: an FDA adverse event reporting system analysis.Frontiers in pharmacology · 2026Article
- Male sex and iron deficiency risk at 6 months: the mediating role of rapid weight gain.Frontiers in nutrition · 2026Article
- Redox on the Clock: Sex-Dependent Dynamics of Xanthine Oxidoreductase Isoforms and Melatonin.International journal of molecular sciences · 2025Article
- Iron-Deficiency Anemia Associated With Prostate Cancer, and Ameliorated by Anti-androgen Therapy.Cureus · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
contextThe mechanisms by which testosterone increases hemoglobin and hematocrit are unknown.
objectiveThe aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory peptide hepcidin.
participantsHealthy younger men (ages 19-35 yr; n = 53) and older men (ages 59-75 yr; n = 56) were studied.
methodsWeekly doses of testosterone enanthate (25, 50, 125, 300, and 600 mg) were administered over 20 wk, whereas endogenous testosterone was suppressed by monthly GnRH agonist administration. Blood and serum parameters from each individual were measured at wk 0, 1, 2, 4, 8, and 20. Longitudinal analyses were performed to examine the relationship between hepcidin, hemoglobin, hematocrit, and testosterone while controlling for potential confounders.
resultsHigh levels of testosterone markedly suppressed serum hepcidin within 1 wk. Hepcidin suppression in response to testosterone administration was dose-dependent in older men and more pronounced than in young men, and this corresponded to a greater rise in hemoglobin in older men. Serum hepcidin levels at 4 and 8 wk were predictive of change in hematocrit from baseline to peak levels.
conclusionTestosterone administration is associated with suppression of serum hepcidin. Greater increases in hematocrit in older men during testosterone therapy are related to greater suppression of hepcidin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.