ArticleDevelopment (Cambridge, England)2010
Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- Multiplexed single cell transcriptomics optimizes mesodermal patterning and hemogenic endothelial output from murine embryonic stem cells.Research square · 2026Article
- Sox17 and Other SoxF-Family Proteins Play Key Roles in the Hematopoiesis of Mouse Embryos.Cells · 2024Review
- Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution.Scientific reports · 2022Article
- Scalable in vitro production of defined mouse erythroblasts.PloS one · 2022Article
- B1 lymphocytes develop independently of Notch signaling during mouse embryonic development.Development (Cambridge, England) · 2021Article
- Harnessing organs-on-a-chip to model tissue regeneration.Cell stem cell · 2021Review
- The hemogenic endothelium: a critical source for the generation of PSC-derived hematopoietic stem and progenitor cells.Cellular and molecular life sciences : CMLS · 2021Review
- The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors.Nature cell biology · 2021Article
- The pluripotency factor NANOG controls primitive hematopoiesis and directly regulatesThe EMBO journal · 2019Article
- Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis.Stem cell reports · 2019Article
- In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.Stem cell reports · 2018Article
- Etv2 as an essential regulator of mesodermal lineage development.Cardiovascular research · 2017Review
- Earlier and broader roles of Mesp1 in cardiovascular development.Cellular and molecular life sciences : CMLS · 2017Review
- The hematopoietic system in the context of regenerative medicine.Methods (San Diego, Calif.) · 2016Review
- A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.Stem cell reports · 2015Article
- Checkpoints that control B cell development.The Journal of clinical investigation · 2015Review
- Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.PLoS genetics · 2015Article
- In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.Stem cell reports · 2015Article
- Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems.Frontiers in biology · 2014Article
- BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways.Blood · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The efficient and reproducible generation of differentiated progenitors from pluripotent stem cells requires the recapitulation of appropriate developmental stages and pathways. Here, we have used the combination of activin A, BMP4 and VEGF under serum-free conditions to induce hematopoietic differentiation from both embryonic and induced pluripotent stem cells, with the aim of modeling the primary sites of embryonic hematopoiesis. We identified two distinct Flk1-positive hematopoietic populations that can be isolated based on temporal patterns of emergence. The earliest arising population displays characteristics of yolk sac hematopoiesis, whereas a late developing Flk1-positive population appears to reflect the para-aortic splanchnopleura hematopoietic program, as it has reduced primitive erythroid capacity and substantially enhanced myeloid and lymphoid potential compared with the earlier wave. These differences between the two populations are accompanied by differences in the expression of Sox17 and Hoxb4, as well as in the cell surface markers AA4.1 and CD41. Together, these findings support the interpretation that the two populations are representative of the early sites of mammalian hematopoiesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.