ArticleProceedings. Biological sciences2011
Evolutionary demography and quantitative genetics: age-specific survival as a threshold trait.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Estimating the Genetic Risk of First-Degree Relatives for Chronic Diseases Using the Short Tandem Repeat Score as Model of Polygenic Inheritance.Biochemical genetics · 2025Article
- A unified framework for evolutionary genetic and physiological theories of aging.PLoS biology · 2024Article
- Intrinsic emergence and modulation of sex-specific dominance reversals in threshold traits.Evolution; international journal of organic evolution · 2022Article
- The Biology of Aging in Insects: FromAnnual review of entomology · 2022Review
- The diversity of maternal-age effects upon pre-adult survival across animal species.Proceedings. Biological sciences · 2020Article
- Heredity Indexes for Estimating Heritability Using Known and Unknown Family Data Based on the Model of Polygenic Inheritance.Computational and mathematical methods in medicine · 2020Article
- Genetics, lifestyle and longevity: Lessons from centenarians.Applied & translational genomics · 2015Review
- Individual fitness and phenotypic selection in age-structured populations with constant growth rates.Ecology · 2014Article
- A demographic transition altered the strength of selection for fitness and age-specific survival and fertility in a 19th century American population.Evolution; international journal of organic evolution · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Researchers must understand how mutations affect survival at various ages to understand how ageing evolves. Many models linking mutation to age-specific survival have been proposed but there is little evidence to indicate which model is most appropriate. This is a serious problem because the predicted evolutionary endpoints of ageing depend upon the details of the specific model. We apply an explicitly quantitative genetic perspective to the problem. To determine the inheritance of dichotomous traits (such as survival), quantitative genetics has long employed a threshold model. Beginning from first principles, we show how this is the most defensible mutational model for age-specific survival and how this, relative to the standard model, predicts delayed senescence and mortality deceleration at late age. These are commonly observed patterns of ageing that heretofore have required more complicated survival models. We also show how this model can be developed further to unify quantitative genetics and evolutionary demography into a more complete conceptual framework for understanding the evolution of ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.