ArticleBiology letters2011
Extreme lifespan of the human fish (Proteus anguinus): a challenge for ageing mechanisms.
Article in Biology letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Neoteny and Evolutionary Strategy: Reconsidering Developmental Arrest in the Axolotl and the Olm.Acta biotheoretica · 2026Article
- The evolution of cancer and ageing: a history of constraint.Nature reviews. Cancer · 2025Review
- State-of-the-Art Age Determination Methods for Amphibians and Reptiles.Animals : an open access journal from MDPI · 2025Review
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells.International journal of molecular sciences · 2024Review
- A practical guide for the husbandry of cave and surface invertebrates as the first step in establishing new model organisms.PloS one · 2024Article
- Review
- Temperature-independent telomere lengthening with age in the long-lived human fish (Proceedings. Biological sciences · 2023Article
- A real data-driven simulation strategy to select an imputation method for mixed-type trait data.PLoS computational biology · 2023Article
- Cavefishes in Chronobiological Research: A Narrative Review.Clocks & sleep · 2023Review
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- Lithology and disturbance drive cavefish and cave crayfish occurrence in the Ozark Highlands ecoregion.Scientific reports · 2022Article
- Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.The EMBO journal · 2022Article
- Exceptional longevity in northern peripheral populations of Wels catfish (Siluris glanis).Scientific reports · 2022Article
- Cultivable Skin Mycobiota of Healthy and Diseased Blind Cave Salamander (Frontiers in microbiology · 2022Article
- Collecting eco-evolutionary data in the dark: Impediments to subterranean research and how to overcome them.Ecology and evolution · 2021Review
- Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans.Biogerontology · 2021Article
- The impact of nitrate on the groundwater assemblages of European unconsolidated aquifers is likely less severe than expected.Environmental science and pollution research international · 2021Article
- Salamander Insights Into Ageing and Rejuvenation.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theories of extreme lifespan evolution in vertebrates commonly implicate large size and predator-free environments together with physiological characteristics like low metabolism and high protection against oxidative damages. Here, we show that the 'human fish' (olm, Proteus anguinus), a small cave salamander (weighing 15-20 g), has evolved an extreme life-history strategy with a predicted maximum lifespan of over 100 years, an adult average lifespan of 68.5 years, an age at sexual maturity of 15.6 years and lays, on average, 35 eggs every 12.5 years. Surprisingly, neither its basal metabolism nor antioxidant activities explain why this animal sits as an outlier in the amphibian size/longevity relationship. This species thus raises questions regarding ageing processes and constitutes a promising model for discovering mechanisms preventing senescence in vertebrates.
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