ArticleRheumatology (Oxford, England)2011
Associations of disease activity and treatments with mortality in men with rheumatoid arthritis: results from the VARA registry.
Article in Rheumatology (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Pooled it
- Examining the Relationship Between Rheumatoid Arthritis, Multimorbidity, and Adverse Health-Related Outcomes: A Systematic Review.Arthritis care & research · 2022Pooled it
- Trial
- Serum cotinine as a biomarker of tobacco exposure and the association with treatment response in early rheumatoid arthritis.Arthritis care & research · 2012Trial
- Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis.Arthritis care & research · 2026Article
- From joints to vessels: How rheumatoid arthritis therapy alters the fate of the heart.World journal of cardiology · 2025Review
- Updating and Validating the Rheumatic Disease Comorbidity Index to Incorporate ICD-10-CM Diagnostic Codes.Arthritis care & research · 2023Article
- Associations of Cost Sharing With Rheumatoid Arthritis Disease Burden.ACR open rheumatology · 2023Article
- Article
- The impact of disease severity measures on survival in U.S. veterans with rheumatoid arthritis-associated interstitial lung disease.Rheumatology (Oxford, England) · 2022Article
- Elevations in adipocytokines and mortality in rheumatoid arthritis.Rheumatology (Oxford, England) · 2022Article
- Adipocytokines and achievement of low disease activity in rheumatoid arthritis.Seminars in arthritis and rheumatism · 2022Article
- Relationship Between Depression and Disease Activity in United States Veterans With Early Rheumatoid Arthritis Receiving Methotrexate.The Journal of rheumatology · 2021Article
- Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis.Annals of the rheumatic diseases · 2021Article
- Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis.Arthritis research & therapy · 2020Article
- Coexistent Hyperuricemia and Gout in Rheumatoid Arthritis: Associations With Comorbidities, Disease Activity, and Mortality.Arthritis care & research · 2020Article
- Disease Activity and Anticitrullinated Peptide Antibody Positivity Predict the Worsening of Ventricular Function in Rheumatoid Arthritis.ACR open rheumatology · 2020Article
- Extraction of Rheumatoid Arthritis Disease Activity Measures From Electronic Health Records Using Automated Processing Algorithms.ACR open rheumatology · 2019Article
- Dynamics of body mass index and visceral adiposity index in patients with rheumatoid arthritis treated with tofacitinib.Rheumatology international · 2019Article
- HLA-DRB1 Haplotypes, Shared Epitope, and Disease Outcomes in US Veterans with Rheumatoid Arthritis.The Journal of rheumatology · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesTo examine the all-cause mortality rate and factors associated with mortality in US veteran men with RA.
methodsMen with RA were enrolled and followed until death or censoring. Vital status was ascertained through systematic record review and standardized mortality ratios (SMRs) were calculated using US life tables for men. Multivariate Cox proportional hazards regression was used to examine the independent associations of patient factors including socio-demographics, comorbidity, measures of RA disease activity/severity and medication use with mortality. Measures of RA disease activity and medications were examined as time-varying factors.
resultsA total of 138 deaths were observed during 2314 patient-years of follow-up (n=1015 patients), corresponding to a crude morality rate of 5.9 deaths per 100 patient-years (95% CI 5.0, 7.0) and an SMR of 2.1 (95% CI 1.8, 2.5). After multivariate adjustment, factors independently associated with higher mortality risk in men with RA included older age, Caucasian race, low body weight, an increased frequency of rheumatology visits, higher ESR and RF concentrations, increased DAS28, subcutaneous nodules and prednisone use. In contrast, MTX use [hazard ratio (HR) 0.63; 95% CI 0.42, 0.96] was associated with ∼40% lower mortality risk.
conclusionMortality rates among US male veterans with RA are more than twice those of age-matched men in the general population. These results suggest that optimizing disease control, particularly with regimens that include MTX and minimize glucocorticoid exposure, could improve long-term survival in this population.
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