ArticleIEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
Optical coherence tomography: the intraoperative assessment of lymph nodes in breast cancer.
Article in IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Cutting Edge Microscopic Intraoperative Tissue Assessment for Guidance in Oncologic Surgery: A Systematic Review of the Role of Optical Coherence Tomography.Annals of surgical oncology · 2025Pooled it
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery.Cancer research · 2015Trial
- Microscopic assessment of lymph node status in gynecological malignancies using full-field optical coherence tomography.Scientific reports · 2025Article
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- Differentiating Primary and Recurrent Lesions in Patients with a History of Breast Cancer: A Comprehensive Review.Galen medical journal · 2024Article
- Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review.Cancers · 2023Review
- Compressed sensing of human breast optical coherence 3-D image volume data using predictive coding.Biomedical optics express · 2023Article
- Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration.Journal of personalized medicine · 2023Article
- Automated analysis framework forBiomedical optics express · 2023Article
- Article
- Current Clinical and Pre-Clinical Imaging Approaches to Study the Cancer-Associated Immune System.Frontiers in immunology · 2021Review
- What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review.Journal of clinical medicine · 2020Review
- Towards an Optical Biopsy during Visceral Surgical Interventions.Visceral medicine · 2020Review
- Volumetric stimulated Raman scattering imaging of cleared tissues towards three-dimensional chemical histopathology.Biomedical optics express · 2019Article
- Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography.Journal of biophotonics · 2018Article
- Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy.Journal of bronchology & interventional pulmonology · 2018Article
- Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements.Journal of biomedical optics · 2017Article
- Review of optical coherence tomography in oncology.Journal of biomedical optics · 2017Review
- Review of intraoperative optical coherence tomography: technology and applications [Invited].Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
Abstract
During breast-conserving surgeries, axillary lymph nodes draining from the primary tumor site are removed for disease staging. Although a high number of lymph nodes are often resected during sentinel and lymph-node dissections, only a relatively small percentage of nodes are found to be metastatic, a fact that must be weighed against potential complications such as lymphedema. Without a real-time in vivo or in situ intraoperative imaging tool to provide a microscopic assessment of the nodes, postoperative paraffin section histopathological analysis currently remains the gold standard in assessing the status of lymph nodes. This paper investigates the use of optical coherence tomography (OCT), a high-resolution real-time microscopic optical-imaging technique, for the intraoperative ex vivo imaging and assessment of axillary lymph nodes. Normal (13), reactive (1), and metastatic (3) lymph nodes from 17 human patients with breast cancer were imaged intraoperatively with OCT. These preliminary clinical studies have identified scattering changes in the cortex, relative to the capsule, which can be used to differentiate normal from reactive and metastatic nodes. These optical scattering changes are correlated with inflammatory and immunological changes observed in the follicles and germinal centers. These results suggest that intraoperative OCT has the potential to assess the real-time node status in situ, without having to physically resect and histologically process specimens to visualize microscopic features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.